Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 5/20 | 0.40 |
| ▸ | RXRB | P28702 | 4/20 | 0.40 |
| ▸ | RXRG | P48443 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561401 | 0.92 | MAOB (0.41) | MAOBRXRARXRBRXRGPTGS2 | |
| SCHEMBL8558565 | 0.91 | PTGS2 (0.44) | MAOBRXRARXRBRXRGPTGS2 | |
| SCHEMBL8559238 | 0.91 | PTGS2 (0.42) | MAOBRXRARXRBRXRGPTGS2 | |
| SCHEMBL8560020 | 0.91 | RXRA (0.39) | MAOBRXRARXRBRXRGPTGS2 | |
| SCHEMBL8559701 | 0.91 | RXRA (0.39) | MAOBRXRARXRBRXRGPTGS2 | |
| SCHEMBL8560576 | 0.88 | RXRA (0.46) | RXRARXRBRXRGPTGS2NPC1 | |
| SCHEMBL8560137 | 0.88 | RXRA (0.49) | MAOBRXRARXRBRXRGNPC1 | |
| SCHEMBL8558000 | 0.87 | RXRA (0.47) | MAOBRXRARXRBRXRGPTGS2 | |
| SCHEMBL8557473 | 0.87 | NR4A2 (0.44) | RXRARXRBRXRGPTGS2PTGS1 | |
| SCHEMBL8555763 | 0.86 | RXRA (0.46) | MAOBRXRARXRBRXRGNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |