Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560797 | 0.84 | ALDH1A1 (0.41) | PLA2G2DCES1MAPK1CES2 | |
| SCHEMBL336060 | 0.82 | KDM4E (0.52) | CES1LMNAMAPK1HTTRAB9A | |
| SCHEMBL15648925 | 0.81 | LTA4H (0.44) | PLA2G2DCES1LMNAMAPK1RAB9A | |
| SCHEMBL8639693 | 0.77 | RAB9A (0.50) | CES1LMNAMAPK1HTTRAB9A | |
| SCHEMBL27952405 | 0.77 | LMNA (0.46) | CES1LMNAMAPK1HTTRAB9A | |
| SCHEMBL121698 | 0.77 | TMPRSS4 (0.44) | CES1RAB9ACES2CA1CA2 | |
| SCHEMBL8559784 | 0.76 | PLA2G2D (0.54) | PLA2G2DCES1HDAC1HDAC6KDM4E | |
| SCHEMBL24166639 | 0.76 | MAPT (0.41) | PLA2G2DCES1MAPK1HTTKDM4E | |
| SCHEMBL2966997 | 0.76 | DGAT1 (0.47) | CES1LMNARAB9AKDM4EGAA | |
| SCHEMBL30531094 | 0.76 | TRPV1 (0.40) | PLA2G2DCES1MAPK1CES2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5747541-A | Substituted benzoylguanidines, a process for their preparation, their use as medicament of diagnostic agent, and medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-05-05 | — | — | US | disclosed |
| EP-0765868-A1 | Substituted bezoyl guanidines, process for their preparation, their use as antiarrhythmics or diagnostic agent as well as pharmaceuticals containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |