Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.39 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561140 | 0.92 | MAPT (0.41) | MAPTALDH1A1MAPK14SLC40A1KDM4E | |
| SCHEMBL8558352 | 0.90 | MAPT (0.42) | MAPTALDH1A1SLC40A1KDM4ECCNT1 | |
| SCHEMBL8561427 | 0.90 | ALDH1A1 (0.42) | MAPTALDH1A1SLC40A1KDM4EMEN1 | |
| SCHEMBL8556636 | 0.89 | MAPT (0.44) | MAPTALDH1A1SLC40A1KDM4ERXFP1 | |
| SCHEMBL8556822 | 0.87 | PIK3CG (0.43) | MAPTALDH1A1SLC40A1KDM4EPIK3CD | |
| SCHEMBL8554227 | 0.87 | CCNT1 (0.49) | MAPTALDH1A1SLC40A1CCNT1CDK9 | |
| SCHEMBL8559708 | 0.84 | MAPT (0.46) | MAPTALDH1A1KDM4ERXFP1MEN1 | |
| SCHEMBL8556998 | 0.84 | PTPN1 (0.44) | MAPTALDH1A1SLC40A1KDM4EMEN1 | |
| SCHEMBL8555551 | 0.84 | MAPT (0.43) | MAPTALDH1A1SLC40A1KDM4ERXFP1 | |
| SCHEMBL8560599 | 0.83 | MAPT (0.46) | MAPTALDH1A1PTGES2SLC40A1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |