SCHEMBL856011

SCHEMBL856011

CCOC(=O)[C@H](C)OC(=O)/C=C/C(=O)O[C@@H](C)C(=O)OCC

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 5/20 0.48
ATM Q13315 1/20 0.39
ALDH1A1 P00352 2/20 0.39
NPSR1 Q6W5P4 1/20 0.38
LMNA P02545 3/20 0.37
HSD17B10 Q99714 1/20 0.37
MAPT P10636 2/20 0.36
ALOX15 P16050 1/20 0.36
MGAM O43451 1/20 0.36
GAA P10253 1/20 0.36
SI P14410 1/20 0.36
MGAM2 Q2M2H8 1/20 0.36
SOAT1 P35610 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA7 P43166 1/20 0.34
CA9 Q16790 1/20 0.34
CA14 Q9ULX7 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL856012 1.00 HCAR2 (0.48) HCAR2ATMALDH1A1NPSR1LMNA
SCHEMBL7045739 1.00 HCAR2 (0.48) HCAR2ATMALDH1A1NPSR1LMNA
SCHEMBL6524281 1.00 HCAR2 (0.48) HCAR2ATMALDH1A1NPSR1LMNA
SCHEMBL13724883 1.00 HCAR2 (0.48) HCAR2ATMALDH1A1NPSR1LMNA
SCHEMBL20562242 0.92 HCAR2 (0.62) HCAR2ATMALDH1A1NPSR1LMNA
SCHEMBL20561333 0.92 HCAR2 (0.62) HCAR2ATMALDH1A1NPSR1LMNA
SCHEMBL20562241 0.92 HCAR2 (0.62) HCAR2ATMALDH1A1NPSR1LMNA
SCHEMBL20561334 0.92 HCAR2 (0.62) HCAR2ATMALDH1A1NPSR1LMNA
SCHEMBL10865325 0.85 MAPT (0.38) HCAR2ALDH1A1NPSR1LMNAHSD17B10
SCHEMBL10865162 0.85 MAPT (0.38) HCAR2ALDH1A1NPSR1LMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019143560-A9 METHODS FOR PROMOTING MITOCHONDRIAL BIOGENESIS IN NEURAL CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-09-12 WO claimed
WO-2019143560-A1 METHODS FOR PROMOTING MITOCHONDRIAL BIOGENESIS IN NEURAL CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-07-25 WO claimed
US-20190111016-A1 METHODS OF TREATING MUSCLE AND LIVER DISORDERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-04-18 US claimed
WO-2017147505-A1 METHODS OF TREATING MUSCLE AND LIVER DISORDERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-08-31 WO claimed
WO-2019143560-A9 METHODS FOR PROMOTING MITOCHONDRIAL BIOGENESIS IN NEURAL CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-09-12 WO disclosed
WO-2019143560-A1 METHODS FOR PROMOTING MITOCHONDRIAL BIOGENESIS IN NEURAL CELLS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-07-25 WO disclosed
US-20190111016-A1 METHODS OF TREATING MUSCLE AND LIVER DISORDERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2019-04-18 US disclosed
US-20180333386-A1 AGENTS USEFUL FOR TREATING FRIEDREICH'S ATAXIA AND OTHER NEURODEGENERATIVE DISEASES IXCHEL PHARMA LLC (US) 2018-11-22 US disclosed
WO-2017147505-A1 METHODS OF TREATING MUSCLE AND LIVER DISORDERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-08-31 WO disclosed
EP-3022188-B1 PIPERAZINE SUBSTITUTED BRIDGED SPIRO[2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2017-06-07 EP disclosed
EP-3013817-B1 DIFLUOROETHYL-OXAZOLE SUBSTITUTED BRIDGED SPIRO[2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2017-04-26 EP disclosed
EP-2850058-B1 1-(P-TOLYL)CYCLOPROPYL SUBSTITUTED BRIDGED SPIRO[2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2016-07-13 EP disclosed
WO-2013171687-A1 1-(P-TOLYL)CYCLOPROPYL SUBSTITUTED BRIDGED SPIRO[2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2013-11-21 WO disclosed
US-8563714-B2 Bridged spiro [2.4] heptane derivatives as ALX receptor and/or FPRL2 agonists ACTELION PHARMACEUTICALS LTD. (CH) 2013-10-22 US disclosed
US-20130231319-A1 Bridged Spiro[2.4]heptane Ester Derivatives ACTELION PHARMACEUTICALS LTD. (CH) 2013-09-05 US disclosed
EP-2432760-B1 BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2013-07-17 EP disclosed
WO-2012149478-A2 AGENTS USEFUL FOR TREATING FRIEDREICH'S ATAXIA AND OTHER NEURODEGENERATIVE DISEASES SERKET PHARMA, LLC (US) 2012-11-01 WO disclosed
US-20120115841-A1 BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS ACTELION PHARMACEUTICALS LTD. (CH) 2012-05-10 US disclosed
EP-2432760-A1 BRIDGED SPIRO [2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS Actelion Pharmaceuticals Ltd. (CH) 2012-03-28 EP disclosed
WO-2010134014-A1 BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS ACTELION PHARMACEUTICALS LTD (CH) 2010-11-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180333386-A1 AGENTS USEFUL FOR TREATING FRIEDREICH'S ATAXIA AND OTHER NEURODEGENERATIVE DISEASES CLN6, NLN, HTT HCAR2 3305/4885ATM 1482/4885ALDH1A1 2592/4885
US-20120115841-A1 BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS FPR1, FPR2, FPR3 HCAR2 23/4885ATM 4427/4885ALDH1A1 1293/4885
US-20190111016-A1 METHODS OF TREATING MUSCLE AND LIVER DISORDERS CKMT1A; CKMT1B, CPT1B, GLS2 HCAR2 2186/4885ATM 4219/4885ALDH1A1 860/4885
US-20130231319-A1 Bridged Spiro[2.4]heptane Ester Derivatives ADH1A, ADH1C, NAPA HCAR2 558/4885ATM 3999/4885ALDH1A1 609/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.