Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.37 |
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560750 | 0.83 | PDE4A (0.52) | ADORA2AADORA3HPGDHSD17B10ADORA2B | |
| SCHEMBL8563746 | 0.83 | ADORA3 (0.39) | ADORA2AADORA3ALDH1A1TDP2KDM4C | |
| SCHEMBL7001583 | 0.72 | ADORA2A (0.49) | ADORA2AADORA3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL8563751 | 0.70 | ADORA3 (0.46) | ADORA2AADORA3POLBADORA2BPDE4A | |
| SCHEMBL8560002 | 0.69 | ADORA1 (0.58) | ADORA2AADORA3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL4983107 | 0.69 | PDE4A (0.60) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL7656833 | 0.68 | KMT2A (0.50) | ADORA2AADORA3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL7659027 | 0.67 | KMT2A (0.50) | KDM4EALDH1A1HSD17B10LMNAPOLB | |
| SCHEMBL7661252 | 0.66 | ADORA1 (0.47) | ADORA2AADORA3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL7666660 | 0.66 | ADORA2B (0.54) | ADORA2AADORA3POLBADORA2BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880524-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | Boehringer Ingelheim Pharma KG (DE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1998003511-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-01-29 | — | — | WO | disclosed |