Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.40 |
| ▸ | MMP9 | P14780 | 3/20 | 0.40 |
| ▸ | MMP8 | P22894 | 3/20 | 0.40 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10438714 | 0.81 | NCF1 (0.41) | RAB9AMAPTNPC1HTTSMN1; SMN2 | |
| SCHEMBL29980485 | 0.81 | NCF1 (0.41) | RAB9AMAPTNPC1HTTSMN1; SMN2 | |
| SCHEMBL28294004 | 0.79 | MAPT (0.48) | RAB9AMAPTNPC1HTTSMN1; SMN2 | |
| SCHEMBL8569476 | 0.78 | MEN1 (0.49) | RAB9AMAPTNPC1SMN1; SMN2MAPK1 | |
| SCHEMBL9776952 | 0.77 | CYP1A2 (0.46) | RAB9AMAPTNPC1HTTSMN1; SMN2 | |
| SCHEMBL2816722 | 0.73 | ALDH1A1 (0.60) | RAB9AMAPTNPC1SMN1; SMN2MAPK1 | |
| SCHEMBL1576857 | 0.73 | ALDH1A1 (0.52) | MAPK1ALDH1A1KMT2AMEN1RECQL | |
| SCHEMBL9595911 | 0.72 | RAB9A (0.65) | RAB9AMAPTNPC1HTTSMN1; SMN2 | |
| SCHEMBL10417424 | 0.71 | MAPT (0.49) | RAB9AMAPTSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8563275 | 0.69 | RAB9A (0.68) | RAB9AMAPTNPC1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |