Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.43 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555034 | 0.90 | ALDH1A1 (0.53) | TSHRPKMNR4A2NR4A1NR4A3 | |
| SCHEMBL8560767 | 0.89 | NR4A2 (0.48) | TSHRPKMHPGDMAPK1NPSR1 | |
| SCHEMBL8554882 | 0.88 | NR4A2 (0.57) | TSHRHPGDMAPK1NPSR1NR4A2 | |
| SCHEMBL8560566 | 0.87 | NR4A2 (0.47) | TSHRPKMHPGDMAPK1NPSR1 | |
| SCHEMBL8560630 | 0.83 | MAPT (0.49) | TSHRHPGDNPSR1KDM4EMAPT | |
| SCHEMBL8557930 | 0.83 | HSD11B1 (0.44) | TSHRHPGDNPSR1NR4A2NR4A1 | |
| SCHEMBL8560085 | 0.81 | KDM4E (0.51) | TSHRHPGDMAPK1NR4A2NR4A1 | |
| SCHEMBL8561174 | 0.81 | TSHR (0.44) | TSHRPKMHPGDMAPK1NPSR1 | |
| SCHEMBL8556747 | 0.81 | RXRA (0.59) | TSHRHPGDMAPK1NR4A2NR4A1 | |
| SCHEMBL8554937 | 0.81 | MAPT (0.44) | TSHRHPGDNPSR1NR4A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | claimed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | claimed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |