Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8567143 | 0.90 | CA1 (0.39) | CTSLMAPTALDH1A1KMT2APOLB | |
| SCHEMBL8575729 | 0.90 | CA1 (0.39) | CTSLMAPTALDH1A1KMT2APOLB | |
| SCHEMBL8845255 | 0.89 | CTSV (0.38) | CTSVCTSLMAPTITGA4ITGB7 | |
| SCHEMBL8997699 | 0.83 | CA1 (0.36) | ALDH1A1RAB9ANPC1HTTPOLB | |
| SCHEMBL8560808 | 0.81 | SYK (0.35) | CTSLMAPTLMNAALDH1A1CA1 | |
| SCHEMBL8574453 | 0.80 | CA1 (0.35) | CTSLMAPTALDH1A1CA1CA2 | |
| SCHEMBL8997600 | 0.80 | SYK (0.40) | MAPTITGA4ITGB7LMNAALDH1A1 | |
| SCHEMBL8573147 | 0.79 | CYP3A4 (0.37) | MAPTALDH1A1 | |
| SCHEMBL8997778 | 0.79 | MEN1 (0.40) | ALDH1A1RAB9AKMT2ANPC1HTT | |
| SCHEMBL8997648 | 0.79 | SYK (0.38) | CTSLCA1CA2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640618-B1 | Tetrahydronaphthalene-peptide derivatives | HOFFMANN LA ROCHE (CH) | 1999-10-20 | — | — | EP | disclosed |
| EP-0640618-A1 | Tetrahydronaphthalene-peptide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-01 | — | — | EP | disclosed |