SCHEMBL8562872

SCHEMBL8562872

CCCC(=O)CC(=O)C(F)(F)Cl

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
FAAH O00519 11/20 0.39
CES1 P23141 8/20 0.38
CES2 O00748 3/20 0.38
MEN1 O00255 1/20 0.38
CYP1A2 P05177 1/20 0.38
KMT2A Q03164 1/20 0.38
HSD17B10 Q99714 1/20 0.38
TSHR P16473 1/20 0.37
HDAC3 O15379 3/20 0.34
HDAC1 Q13547 3/20 0.34
HDAC2 Q92769 3/20 0.34
HDAC8 Q9BY41 3/20 0.34
HDAC6 Q9UBN7 1/20 0.34
FFAR3 O14843 2/20 0.33
CTSD P07339 1/20 0.33
HAO1 Q9UJM8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11517662 0.82 TDP1 (0.41) FAAHCES1CES2MEN1CYP1A2
SCHEMBL6314290 0.82 FAAH (0.52) FAAHCES1CES2MEN1CYP1A2
SCHEMBL19320231 0.78 FAAH (0.39) FAAHCES1CES2MEN1CYP1A2
SCHEMBL23009369 0.77 FAAH (0.38) FAAHCES1CES2MEN1CYP1A2
SCHEMBL11516509 0.75 ALDH1A1 (0.32) MEN1KMT2ATSHR
SCHEMBL5705918 0.75 CES1 (0.39) FAAHCES1CES2MEN1CYP1A2
Calcium SCHEMBL30593430 0.73 CES1 (0.38) FAAHCES1CES2MEN1CYP1A2
Fluoride SCHEMBL27465108 0.73 CES1 (0.38) FAAHCES1CES2MEN1CYP1A2
SCHEMBL26185744 0.73 CES1 (0.38) FAAHCES1CES2MEN1CYP1A2
SCHEMBL1701664 0.72 CES2 (0.53) CES1CES2TSHRHDAC3HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5716904-A FOR BROARD LEAF WEEDS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1998-02-10 US disclosed
EP-0764641-A1 NOVEL 4,5-DISUBSTITUTED PYRIMIDINE DERIVATIVE AND HERBICIDE NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) 1997-03-26 EP disclosed
US-4180386-A ANTIKNOCK FUEL ADDITIVES E. I. DU PONT DE NEMOURS & COMPANY (US) 1979-12-25 US disclosed