Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.52 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562633 | 0.92 | AVPR2 (0.55) | SMN1; SMN2AVPR2AVPR1ANPC1RAB9A | |
| SCHEMBL8562828 | 0.84 | AVPR2 (0.49) | SMN1; SMN2AVPR2AVPR1ANPC1RAB9A | |
| SCHEMBL8562097 | 0.84 | AVPR2 (0.49) | SMN1; SMN2AVPR2AVPR1ANPC1RAB9A | |
| SCHEMBL8557607 | 0.83 | NPC1 (0.50) | AVPR2AVPR1ANPC1RAB9AMAPT | |
| SCHEMBL8556275 | 0.83 | AVPR2 (0.69) | AVPR2AVPR1A | |
| SCHEMBL8558857 | 0.83 | HPGD (0.57) | SMN1; SMN2NAMPTNPC1RAB9AMEN1 | |
| SCHEMBL7333170 | 0.83 | AVPR1A (0.66) | AVPR2AVPR1A | |
| SCHEMBL8557068 | 0.80 | AVPR2 (0.57) | AVPR2AVPR1ANAMPTNPC1RAB9A | |
| SCHEMBL8560873 | 0.79 | ACHE (0.60) | AVPR2AVPR1ANAMPTRAB9A | |
| SCHEMBL8560800 | 0.79 | AVPR2 (0.79) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |