SCHEMBL8563403

SCHEMBL8563403

C=COCCOC(=O)c1c(F)c(F)cc(F)c1F

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CA1 P00915 6/20 0.39
CA2 P00918 6/20 0.39
CA4 P22748 2/20 0.39
ESR1 P03372 1/20 0.37
SERPINE1 P05121 4/20 0.36
LMNA P02545 2/20 0.36
TSHR P16473 1/20 0.31
NPC1 O15118 1/20 0.31
HPGD P15428 1/20 0.31
MAPK1 P28482 1/20 0.31
RAB9A P51151 1/20 0.31
CA9 Q16790 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8567444 0.86 ESR1 (0.45) CA1CA2ESR1LMNATSHR
SCHEMBL31448662 0.86 CA1 (0.50) CA1CA2CA4ESR1SERPINE1
SCHEMBL16281984 0.80 TSHR (0.37) ESR1SERPINE1LMNATSHRNPC1
SCHEMBL19795497 0.76 ESR1 (0.53) CA1CA2CA4ESR1LMNA
SCHEMBL15844998 0.75 TSHR (0.44) SERPINE1LMNATSHRNPC1HPGD
SCHEMBL276085 0.75 SERPINE1 (0.52) CA1CA2ESR1SERPINE1CA9
SCHEMBL2832910 0.74 ESR1 (0.37) CA1CA2CA4ESR1SERPINE1
SCHEMBL1151105 0.74 KDM4E (0.47) LMNATSHRHPGDMAPK1CA9
SCHEMBL8565259 0.73 GPR17 (0.35) LMNAHPGD
SCHEMBL16285470 0.73 TSHR (0.42) SERPINE1LMNATSHRNPC1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9459533-B2 Polymer composition, photoresist comprising the polymer composition, and coated article comprising the photoresist DOW GLOBAL TECHNOLOGIES LLC (US) 2016-10-04 US disclosed
US-9459533-B2 Polymer composition, photoresist comprising the polymer composition, and coated article comprising the photoresist DOW GLOBAL TECHNOLOGIES LLC (US) 2016-10-04 US disclosed
US-8936900-B2 Calixarene and photoresist composition comprising same ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2015-01-20 US disclosed
US-8936900-B2 Calixarene and photoresist composition comprising same ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2015-01-20 US disclosed
US-8765356-B2 Calixarene compound and photoresist composition comprising same DOW GLOBAL TECHNOLOGIES LLC (US) 2014-07-01 US disclosed
US-8765356-B2 Calixarene compound and photoresist composition comprising same DOW GLOBAL TECHNOLOGIES LLC (US) 2014-07-01 US disclosed
US-8703383-B2 Photosensitive copolymer and photoresist composition ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2014-04-22 US disclosed
US-8703383-B2 Photosensitive copolymer and photoresist composition ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2014-04-22 US disclosed
US-20130157195-A1 CALIXARENE COMPOUND AND PHOTORESIST COMPOSITION COMPRISING SAME ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2013-06-20 US disclosed
US-20130157195-A1 CALIXARENE COMPOUND AND PHOTORESIST COMPOSITION COMPRISING SAME ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2013-06-20 US disclosed
US-20130078569-A1 CALIXARENE AND PHOTORESIST COMPOSITION COMPRISING SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2013-03-28 US disclosed
US-20130078569-A1 CALIXARENE AND PHOTORESIST COMPOSITION COMPRISING SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2013-03-28 US disclosed
US-20120129105-A1 PHOTOSENSITIVE COPOLYMER AND PHOTORESIST COMPOSITION ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2012-05-24 US disclosed
US-20120129105-A1 PHOTOSENSITIVE COPOLYMER AND PHOTORESIST COMPOSITION ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2012-05-24 US disclosed
EP-2455812-A2 Photosensitive copolymer and photoresist composition Rohm and Haas Electronic Materials LLC (US) 2012-05-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130157195-A1 CALIXARENE COMPOUND AND PHOTORESIST COMPOSITION COMPRISING SAME CALU, UACA, HCAR1 CA1 339/4885CA2 384/4885CA4 94/4885
US-20130078569-A1 CALIXARENE AND PHOTORESIST COMPOSITION COMPRISING SAME ARL1, GRK1, AAK1 CA1 1532/4885CA2 832/4885CA4 1527/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.