SCHEMBL8565259

SCHEMBL8565259

C=COCCOC(=O)c1c(C(F)(F)F)cc(C(F)(F)F)cc1C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR17 Q13304 1/20 0.35
CES2 O00748 3/20 0.34
L3MBTL1 Q9Y468 2/20 0.33
ALDH1A1 P00352 2/20 0.33
LMNA P02545 2/20 0.33
NOTUM Q6P988 1/20 0.33
CACNA1H O95180 1/20 0.33
TXNRD1 Q16881 1/20 0.33
ELANE P08246 1/20 0.32
GPR35 Q9HC97 1/20 0.32
SLC13A3 Q8WWT9 1/20 0.32
TDP1 Q9NUW8 1/20 0.31
RXRA P19793 1/20 0.31
RXRB P28702 1/20 0.31
RXRG P48443 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
HPGD P15428 1/20 0.30
POLQ O75417 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8798042 0.87 L3MBTL1 (0.38) L3MBTL1ALDH1A1LMNATXNRD1ELANE
SCHEMBL14818787 0.77 TDP1 (0.46) CES2L3MBTL1ALDH1A1LMNATDP1
SCHEMBL16281984 0.76 TSHR (0.37) ALDH1A1LMNAHPGD
SCHEMBL8563403 0.73 CA1 (0.39) LMNAHPGD
SCHEMBL8567444 0.72 ESR1 (0.45) ALDH1A1LMNA
SCHEMBL276085 0.71 SERPINE1 (0.52) L3MBTL1TDP1
SCHEMBL15844998 0.71 TSHR (0.44) L3MBTL1ALDH1A1LMNATDP1HPGD
SCHEMBL31031802 0.70 CES2 (0.43) GPR17CES2NOTUMGPR35RXRA
SCHEMBL31031798 0.70 CES2 (0.43) GPR17CES2NOTUMGPR35RXRA
SCHEMBL16285470 0.68 TSHR (0.42) L3MBTL1ALDH1A1LMNATDP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9459533-B2 Polymer composition, photoresist comprising the polymer composition, and coated article comprising the photoresist DOW GLOBAL TECHNOLOGIES LLC (US) 2016-10-04 US disclosed
US-8936900-B2 Calixarene and photoresist composition comprising same ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2015-01-20 US disclosed
US-8765356-B2 Calixarene compound and photoresist composition comprising same DOW GLOBAL TECHNOLOGIES LLC (US) 2014-07-01 US disclosed
US-8703383-B2 Photosensitive copolymer and photoresist composition ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2014-04-22 US disclosed
US-20130157195-A1 CALIXARENE COMPOUND AND PHOTORESIST COMPOSITION COMPRISING SAME ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2013-06-20 US disclosed
US-20130078569-A1 CALIXARENE AND PHOTORESIST COMPOSITION COMPRISING SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2013-03-28 US disclosed
US-20120129105-A1 PHOTOSENSITIVE COPOLYMER AND PHOTORESIST COMPOSITION ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2012-05-24 US disclosed
EP-2455812-A2 Photosensitive copolymer and photoresist composition Rohm and Haas Electronic Materials LLC (US) 2012-05-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130157195-A1 CALIXARENE COMPOUND AND PHOTORESIST COMPOSITION COMPRISING SAME CALU, UACA, HCAR1 GPR17 59/4885CES2 2389/4885L3MBTL1 4756/4885
US-20130078569-A1 CALIXARENE AND PHOTORESIST COMPOSITION COMPRISING SAME ARL1, GRK1, AAK1 GPR17 539/4885CES2 1402/4885L3MBTL1 3151/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.