SCHEMBL8567444

SCHEMBL8567444

C=COCCOC(=O)c1c(F)c(F)c(F)c(F)c1F

nearest known ligand 0.45

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.45
CA1 P00915 3/20 0.44
CA2 P00918 3/20 0.44
RECQL P46063 1/20 0.35
LMNA P02545 1/20 0.33
TSHR P16473 4/20 0.31
ALDH1A1 P00352 2/20 0.31
TP53 P04637 2/20 0.31
HIF1A Q16665 2/20 0.31
HSD17B10 Q99714 1/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8563403 0.86 CA1 (0.39) ESR1CA1CA2LMNATSHR
SCHEMBL16281984 0.86 TSHR (0.37) ESR1LMNATSHRALDH1A1TP53
Ethylene SCHEMBL4583799 0.84 ESR1 (0.53) ESR1CA1CA2RECQLTSHR
SCHEMBL4582621 0.84 ESR1 (0.57) ESR1CA1CA2RECQLTSHR
SCHEMBL2833921 0.79 ESR1 (0.46) ESR1CA1CA2RECQLTSHR
Ammonia Solution, Strong SCHEMBL27753138 0.77 ESR1 (0.51) ESR1CA1CA2RECQLTSHR
SCHEMBL2835314 0.76 ESR1 (0.51) ESR1CA1CA2RECQLLMNA
SCHEMBL13291852 0.76 ESR1 (0.63) ESR1CA1CA2RECQLLMNA
SCHEMBL17367967 0.76 ESR1 (0.63) ESR1CA1CA2RECQLTSHR
SCHEMBL2833749 0.75 CYP3A4 (0.50) ESR1CA1CA2LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023227577-A1 HYDROPHILIC COATINGS FOR VASCULAR MEDICAL PRODUCTS BIOTRONIK AG (CH) 2023-11-30 WO disclosed
US-9459533-B2 Polymer composition, photoresist comprising the polymer composition, and coated article comprising the photoresist DOW GLOBAL TECHNOLOGIES LLC (US) 2016-10-04 US disclosed
US-9459533-B2 Polymer composition, photoresist comprising the polymer composition, and coated article comprising the photoresist DOW GLOBAL TECHNOLOGIES LLC (US) 2016-10-04 US disclosed
US-8936900-B2 Calixarene and photoresist composition comprising same ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2015-01-20 US disclosed
US-8936900-B2 Calixarene and photoresist composition comprising same ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2015-01-20 US disclosed
US-8765356-B2 Calixarene compound and photoresist composition comprising same DOW GLOBAL TECHNOLOGIES LLC (US) 2014-07-01 US disclosed
US-8765356-B2 Calixarene compound and photoresist composition comprising same DOW GLOBAL TECHNOLOGIES LLC (US) 2014-07-01 US disclosed
US-8703383-B2 Photosensitive copolymer and photoresist composition ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2014-04-22 US disclosed
US-8703383-B2 Photosensitive copolymer and photoresist composition ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2014-04-22 US disclosed
US-20130157195-A1 CALIXARENE COMPOUND AND PHOTORESIST COMPOSITION COMPRISING SAME ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2013-06-20 US disclosed
US-20130157195-A1 CALIXARENE COMPOUND AND PHOTORESIST COMPOSITION COMPRISING SAME ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2013-06-20 US disclosed
US-20130078569-A1 CALIXARENE AND PHOTORESIST COMPOSITION COMPRISING SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2013-03-28 US disclosed
US-20130078569-A1 CALIXARENE AND PHOTORESIST COMPOSITION COMPRISING SAME DOW GLOBAL TECHNOLOGIES LLC (US) 2013-03-28 US disclosed
US-20120129105-A1 PHOTOSENSITIVE COPOLYMER AND PHOTORESIST COMPOSITION ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2012-05-24 US disclosed
US-20120129105-A1 PHOTOSENSITIVE COPOLYMER AND PHOTORESIST COMPOSITION ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2012-05-24 US disclosed
EP-2455812-A2 Photosensitive copolymer and photoresist composition Rohm and Haas Electronic Materials LLC (US) 2012-05-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130157195-A1 CALIXARENE COMPOUND AND PHOTORESIST COMPOSITION COMPRISING SAME CALU, UACA, HCAR1 ESR1 258/4885CA1 339/4885CA2 384/4885
US-20130078569-A1 CALIXARENE AND PHOTORESIST COMPOSITION COMPRISING SAME ARL1, GRK1, AAK1 ESR1 562/4885CA1 1532/4885CA2 832/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.