Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | CASP7 | P55210 | 1/20 | 0.52 |
| ▸ | HBB | P68871 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ANXA2 | P07355 | 1/20 | 0.50 |
| ▸ | S100A10 | P60903 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL761802 | 0.86 | LMNA (0.57) | CYP3A4MAPK1ALDH1A1HSD17B10LMNA | |
| SCHEMBL30832956 | 0.86 | LMNA (0.57) | CYP3A4MAPK1ALDH1A1HSD17B10LMNA | |
| SCHEMBL3281214 | 0.84 | LMNA (0.52) | CYP3A4MAPK1ALDH1A1HSD17B10LMNA | |
| SCHEMBL1100970 | 0.79 | CYP3A4 (0.70) | CYP3A4MAPK1TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL11300299 | 0.79 | ALDH1A1 (0.50) | CYP3A4MAPK1ALDH1A1HSD17B10LMNA | |
| SCHEMBL202221 | 0.79 | CYP3A4 (0.78) | CYP3A4MAPK1TSHRALDH1A1HSD17B10 | |
| SCHEMBL14176682 | 0.78 | CYP2A6 (0.60) | CYP3A4MAPK1TSHRALDH1A1HSD17B10 | |
| SCHEMBL8514752 | 0.78 | LMNA (0.47) | MAPK1ALDH1A1HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL12952450 | 0.78 | LMNA (0.47) | CYP3A4MAPK1ALDH1A1HSD17B10LMNA | |
| 4,4'-Thiodianiline SCHEMBL28778309 | 0.78 | CYP3A4 (0.88) | CYP3A4MAPK1TSHRALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |
| US-4072696-A | 5(6)-Benzene ring substituted benzimidazole-2-carbamate derivatives having anthelmintic activity | SYNTEX (U.S.A.) INC. (US) | 1978-02-07 | — | — | US | disclosed |