SCHEMBL8514752

SCHEMBL8514752

c1ccc(-c2ccc(Sc3ccc4ccccc4c3)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
ESR1 P03372 3/20 0.47
ESR2 Q92731 3/20 0.47
HAO1 Q9UJM8 1/20 0.44
MAP2K2 P36507 1/20 0.44
MAP2K1 Q02750 1/20 0.44
HSD17B1 P14061 1/20 0.44
HSD17B2 P37059 1/20 0.44
CYP1A1 P04798 1/20 0.43
CYP1B1 Q16678 1/20 0.43
SIRT2 Q8IXJ6 1/20 0.42
SIRT1 Q96EB6 1/20 0.42
SIRT3 Q9NTG7 1/20 0.42
KDM4E B2RXH2 2/20 0.42
KMT2A Q03164 2/20 0.42
GSTP1 P09211 1/20 0.42
MAPT P10636 1/20 0.42
PKM P14618 1/20 0.42
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3281214 0.89 LMNA (0.52) LMNASMN1; SMN2HAO1MAP2K2MAP2K1
SCHEMBL30832956 0.86 LMNA (0.57) LMNASMN1; SMN2HAO1MAP2K2MAP2K1
SCHEMBL761802 0.86 LMNA (0.57) LMNASMN1; SMN2HAO1MAP2K2MAP2K1
SCHEMBL28209874 0.83 ALDH1A1 (0.56) LMNAKDM4EKMT2AMAPTMAPK1
SCHEMBL27902166 0.83 ALDH1A1 (0.56) LMNAKDM4EKMT2AMAPTMAPK1
SCHEMBL21603033 0.83 ALDH1A1 (0.56) LMNAKDM4EKMT2AMAPTMAPK1
SCHEMBL8516000 0.83 ALDH1A1 (0.56) LMNAKDM4EKMT2AMAPTMAPK1
SCHEMBL28033978 0.83 ALDH1A1 (0.56) LMNAKDM4EKMT2AMAPTMAPK1
SCHEMBL25985531 0.83 ALDH1A1 (0.51) LMNASMN1; SMN2HSD17B1HSD17B2CYP1A1
SCHEMBL7708311 0.82 MAOA (0.48) LMNASMN1; SMN2HAO1MAP2K2MAP2K1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8932797-B2 Photoacid generators DOW GLOBAL TECHNOLOGIES LLC (US) 2015-01-13 US disclosed
US-20120141939-A1 PHOTOACID GENERATORS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS NOTES COLLATERAL AGENT 2012-06-07 US disclosed
EP-2458440-A1 Photoacid generators Rohm and Haas Electronic Materials LLC (US) 2012-05-30 EP disclosed
EP-2458440-A1 Photoacid generators Rohm and Haas Electronic Materials LLC (US) 2012-05-30 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120141939-A1 PHOTOACID GENERATORS F10, GNG2, H1-0 LMNA 3191/4885SMN1; SMN2 4311/4885ESR1 1063/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.