Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MDM4 | O15151 | 2/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.38 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.38 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.38 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.38 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052087 | 0.85 | TUBB4A (0.48) | GPR17ALOX15GSK3BTNKS2ALDH1A1 | |
| SCHEMBL7848100 | 0.81 | GPR17 (0.42) | GPR17ALOX15GSK3BTNKS2ALDH1A1 | |
| SCHEMBL8570658 | 0.74 | TSHR (0.47) | GSK3BALDH1A1KDM4ETSHRMEN1 | |
| SCHEMBL20494685 | 0.73 | ALOX15 (0.54) | GPR17ALOX15MDM2TNKS2ALDH1A1 | |
| SCHEMBL30071216 | 0.73 | ALOX15 (0.54) | GPR17ALOX15MDM2TNKS2ALDH1A1 | |
| SCHEMBL8564247 | 0.69 | ASAH1 (0.39) | GSK3BALDH1A1KMT2A | |
| SCHEMBL7498588 | 0.67 | ALDH1A1 (0.42) | GPR17TNKS2ALDH1A1KDM4ETSHR | |
| SCHEMBL20567601 | 0.66 | ALOX15 (0.51) | ALOX15ALDH1A1KDM4ETSHRMTNR1A | |
| SCHEMBL20495120 | 0.66 | TNKS2 (0.52) | GPR17ALOX15GSK3BTNKS2ALDH1A1 | |
| SCHEMBL20570227 | 0.66 | GPR17 (0.52) | GPR17ALOX15GSK3BMDM2TNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821685-A1 | INDOLE-3-CARBONYL AND INDOLE-3-SULFONYL DERIVATIVES AS PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1998-02-04 | — | — | EP | disclosed |