Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 4/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 5/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8571710 | 0.87 | PRCP (0.42) | PRCPDRD2SIGMAR1LMNAGAA | |
| SCHEMBL8565038 | 0.87 | CHRM3 (0.47) | CCR5CHRM2CHRM3SIGMAR1P2RX7 | |
| SCHEMBL8562015 | 0.81 | TNKS (0.36) | SIGMAR1TNKSTNKS2TP53BRD4 | |
| SCHEMBL8573043 | 0.80 | SIGMAR1 (0.43) | CCR5OPRD1CHRM2CHRM3SIGMAR1 | |
| SCHEMBL8570094 | 0.77 | CHRM3 (0.51) | CHRM2CHRM3DRD2SIGMAR1P2RX7 | |
| SCHEMBL8565096 | 0.77 | CCR5 (0.48) | CCR5CHRM2CHRM3SIGMAR1OPRL1 | |
| SCHEMBL8570739 | 0.76 | CHRM2 (0.54) | CCR5OPRD1CHRM2CHRM3SIGMAR1 | |
| SCHEMBL6168102 | 0.74 | CHRM3 (0.42) | CCR5OPRD1CHRM3DRD2OPRL1 | |
| SCHEMBL6168606 | 0.73 | OPRL1 (0.52) | CCR5CHRM2CHRM3DRD2OPRL1 | |
| SCHEMBL8564971 | 0.73 | TACR1 (0.43) | PRCPDRD2OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626373-B1 | Quinazolinone derivatives | SUMITOMO PHARMA (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5556860-A | ANTIISCHEMIC AGENTS, BRAIN DISORDERS AND BLOOD METAL CONCENTRATIONS AND KIDNEY DISEASE | SUMITOMO PHARMACEUTICALS CO., LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| EP-0626373-A1 | Quinazolinone derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1994-11-30 | — | — | EP | disclosed |