Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.31 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564893 | 1.00 | ESR1 (0.39) | ESR1ESR2PDK2HDAC6PDE4B | |
| SCHEMBL8562237 | 0.87 | ESR1 (0.39) | ESR1ESR2HDAC6PDE4BPDE4D | |
| SCHEMBL8562233 | 0.87 | ESR1 (0.39) | ESR1ESR2HDAC6PDE4BPDE4D | |
| SCHEMBL7418940 | 0.82 | ESR1 (0.42) | ESR1ESR2HDAC6ABHD6 | |
| SCHEMBL7415517 | 0.77 | DRD2 (0.43) | — | |
| SCHEMBL7476926 | 0.76 | DRD2 (0.32) | — | |
| SCHEMBL7476930 | 0.76 | DRD2 (0.32) | — | |
| SCHEMBL8562566 | 0.74 | DRD2 (0.35) | LPAR5 | |
| SCHEMBL8562570 | 0.74 | DRD2 (0.35) | LPAR5 | |
| SCHEMBL7472118 | 0.73 | ESR1 (0.41) | ESR1ESR2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612741-B1 | Cyclic derivatives, medicaments containing them and process for their preparation | THOMAE GMBH DR K (DE) | 1998-06-10 | — | — | EP | disclosed |
| US-5612335-A | ANTICOAGULANTS; COMBATING/PREVENTING DISEASES WHERE CELL AGGREGATES OCCUR OR CELL-MATRIX INTERACTIONS PLAY A PART | KARL THOMAE GMBH (DE) | 1997-03-18 | — | — | US | disclosed |
| US-5519036-A | IMIDAZOLIDINONES, ANTICOAGULANTS, CELL AGGREGATION PREVENTION | KARL THOMAE GMBH (DE) | 1996-05-21 | — | — | US | disclosed |
| EP-0612741-A1 | Cyclic derivatives, medicaments containing them and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1994-08-31 | — | — | EP | disclosed |