Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.46 |
| ▸ | EDNRB | P24530 | 17/20 | 0.46 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | IL2 | P60568 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5174048 | 0.78 | EDNRB (0.41) | EDNRAEDNRBACLY | |
| SCHEMBL8566290 | 0.71 | EDNRA (0.51) | EDNRAEDNRB | |
| SCHEMBL1804383 | 0.70 | HPGDS (0.56) | EDNRAEDNRBACLY | |
| SCHEMBL5029384 | 0.70 | ALDH1A1 (0.47) | EDNRAEDNRBIL2 | |
| SCHEMBL3031254 | 0.69 | RAB9A (0.53) | — | |
| SCHEMBL8628488 | 0.69 | HPGDS (0.51) | EDNRAEDNRBIL2 | |
| SCHEMBL5445930 | 0.69 | IL2 (0.43) | EDNRAEDNRBIL2 | |
| SCHEMBL6641034 | 0.68 | EDNRA (0.79) | EDNRAEDNRB | |
| SCHEMBL5034948 | 0.68 | P2RX7 (0.52) | IL2 | |
| SCHEMBL7868303 | 0.67 | EDNRB (0.56) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762182-B1 | FORMING ESTER OR SECONDARY AMIDE DERIVATIVE OF SUCH AS INDOMETHACIN | VANDERBILT UNIVERSITY | 2004-07-13 | — | — | US | disclosed |