SCHEMBL8566404

SCHEMBL8566404

OCC1(OCc2ccccc2)CO1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.40
ALDH1A1 P00352 3/20 0.40
SLC1A3 P43003 2/20 0.38
SLC1A2 P43004 2/20 0.38
SLC1A1 P43005 2/20 0.38
CYP1A2 P05177 2/20 0.38
CYP2C19 P33261 2/20 0.38
LMNA P02545 2/20 0.38
MEN1 O00255 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
KMT2A Q03164 1/20 0.38
IDO1 P14902 1/20 0.38
AGXT P21549 1/20 0.36
PTGS1 P23219 1/20 0.36
SLC6A2 P23975 1/20 0.36
PTGS2 P35354 1/20 0.36
SLC6A3 Q01959 1/20 0.36
HIF1A Q16665 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27740111 0.81 ALDH1A1 (0.40) TSHRALDH1A1IDO1AGXTMAPK1
SCHEMBL31680308 0.80 ALDH1A1 (0.34) TSHRALDH1A1SLC1A3SLC1A2SLC1A1
SCHEMBL15130271 0.76 TSHR (0.39) TSHRALDH1A1SLC1A3SLC1A2SLC1A1
SCHEMBL29552477 0.73 TSHR (0.43) TSHRALDH1A1IDO1AGXTMAPK1
SCHEMBL20551920 0.73 TSHR (0.43) TSHRALDH1A1SLC1A3SLC1A2SLC1A1
SCHEMBL7294202 0.73 TSHR (0.43) TSHRALDH1A1IDO1AGXTMAPK1
SCHEMBL8558732 0.71 TSHR (0.47) TSHRALDH1A1LMNAMEN1KMT2A
SCHEMBL27973569 0.71 ALDH1A1 (0.38) TSHRALDH1A1IDO1AGXT
SCHEMBL9384798 0.71 MAOA (0.42) TSHRALDH1A1LMNAMEN1KMT2A
SCHEMBL9020639 0.70 TSHR (0.40) TSHRALDH1A1SLC1A3SLC1A2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5837868-A REACTION OF DIHYDROXY OLEFINS IN A MULTISTAGE PROCESS ARYL METHYLAMINE TO FORM PYRROLIDINE INTERMEDIATE ABBOTT LABORATORIES (US) 1998-11-17 US disclosed
US-5703244-A CYCLIZATION OF DIHYDROXY OLEFINS WITH TARTRATE ESTER IN PRESENCE OF TITANIUM ISOPROPOXIDE AND TERT-BUTYL HYDROPEROXIDE ABBOTT LABORATORIES (US) 1997-12-30 US disclosed