Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.47 |
| ▸ | DRD2 | P14416 | 6/20 | 0.46 |
| ▸ | HTR1A | P08908 | 5/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569210 | 0.84 | HTR1A (0.62) | CYP1A2CYP3A4CYP2D6HSD17B10CYP2C19 | |
| SCHEMBL8565869 | 0.79 | HTR1A (0.67) | CYP1A2CYP3A4CYP2D6HSD17B10HRH4 | |
| SCHEMBL8564814 | 0.77 | MAPT (0.45) | ALDH1A1LMNATSHRHTT | |
| SCHEMBL11952724 | 0.74 | HRH4 (0.52) | CYP1A2CYP3A4CYP2D6HSD17B10CYP2C19 | |
| SCHEMBL26647139 | 0.72 | HTT (0.56) | CYP1A2CYP3A4CYP2D6HSD17B10CYP2C19 | |
| SCHEMBL30828999 | 0.72 | HTT (0.56) | CYP1A2CYP3A4CYP2D6HSD17B10CYP2C19 | |
| SCHEMBL13722300 | 0.67 | HSD11B1 (0.57) | CYP1A2CYP3A4CYP2D6HSD17B10HRH4 | |
| SCHEMBL12844776 | 0.64 | HRH4 (1.00) | CYP1A2CYP3A4CYP2D6HSD17B10CYP2C19 | |
| SCHEMBL424507 | 0.63 | DRD2 (0.75) | ALDH1A1LMNAMAPK1HRH4DRD2 | |
| SCHEMBL14046598 | 0.63 | HRH4 (0.56) | CYP1A2CYP3A4CYP2D6HSD17B10CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826674-A1 | NOVEL PYRIMIDINE DERIVATIVES EFFICACIOUS AS PSYCHOTROPIC DRUG AND PROCESS FOR THE PRODUCTION THEREOF | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-03-04 | — | — | EP | disclosed |