Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565133 | 0.89 | ALDH1A1 (0.61) | NPSR1NPC1ADORA3ALDH1A1KDM4E | |
| SCHEMBL8570794 | 0.86 | ADORA3 (0.62) | NPC1ADORA3ALDH1A1KDM4ERXFP1 | |
| SCHEMBL8565123 | 0.82 | ALDH1A1 (0.49) | NPC1ALDH1A1KDM4EHTTMEN1 | |
| SCHEMBL8570956 | 0.81 | ADORA3 (0.53) | NPSR1NPC1ADORA3ALDH1A1KDM4E | |
| SCHEMBL8573320 | 0.79 | NPC1 (0.44) | NPC1ALDH1A1KDM4EHTTMEN1 | |
| SCHEMBL8570862 | 0.78 | ADORA3 (0.59) | NPC1ADORA3ALDH1A1KDM4ERXFP1 | |
| SCHEMBL30911334 | 0.77 | ADORA3 (0.61) | NPC1ADORA3KDM4ERXFP1KMT2A | |
| SCHEMBL8575278 | 0.77 | ADORA3 (0.51) | NPC1ADORA3ALDH1A1KDM4ERXFP1 | |
| SCHEMBL1377141 | 0.76 | ADORA3 (0.68) | NPC1ADORA3RXFP1MEN1KMT2A | |
| SCHEMBL8568489 | 0.75 | NPC1 (0.48) | NPC1ALDH1A1KDM4EHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5705650-A | Process for preparing 1,2,4-thiadiazole derivatives | KATAYAMA SEIYAKUSYO CO., LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5585494-A | Process for preparing 1,2,4-thiadiazole derivatives | KATAYAMA SEIYAKUSYO CO. LTD. (JP) | 1996-12-17 | — | — | US | disclosed |
| EP-0536900-A2 | Process for preparing 1,2,4-Thiadiazole Derivatives | KATAYAMA SEIYAKUSYO CO. Ltd. (JP) | 1993-04-14 | — | — | EP | disclosed |