Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570794 | 0.83 | ADORA3 (0.62) | ADORA3NPC1RXFP1ALDH1A1RAB9A | |
| SCHEMBL8574002 | 0.80 | NPC1 (0.45) | NPC1ALDH1A1RAB9ASMN1; SMN2PKM | |
| SCHEMBL8566680 | 0.78 | NPSR1 (0.60) | ADORA3NPC1RXFP1ALDH1A1RAB9A | |
| SCHEMBL8569667 | 0.76 | SMN1; SMN2 (0.46) | ADORA3NPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8565133 | 0.76 | ALDH1A1 (0.61) | ADORA3NPC1RXFP1ALDH1A1RAB9A | |
| SCHEMBL8570956 | 0.76 | ADORA3 (0.53) | ADORA3NPC1RXFP1ALDH1A1RAB9A | |
| SCHEMBL1377141 | 0.75 | ADORA3 (0.68) | ADORA3NPC1RXFP1RAB9ASMN1; SMN2 | |
| SCHEMBL29530821 | 0.75 | ADORA3 (1.00) | ADORA3NPC1RXFP1RAB9ASMN1; SMN2 | |
| SCHEMBL8575278 | 0.74 | ADORA3 (0.51) | ADORA3NPC1RXFP1ALDH1A1RAB9A | |
| SCHEMBL8572006 | 0.74 | NPC1 (0.37) | ADORA3NPC1ALDH1A1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5705650-A | Process for preparing 1,2,4-thiadiazole derivatives | KATAYAMA SEIYAKUSYO CO., LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5585494-A | Process for preparing 1,2,4-thiadiazole derivatives | KATAYAMA SEIYAKUSYO CO. LTD. (JP) | 1996-12-17 | — | — | US | disclosed |
| EP-0536900-A2 | Process for preparing 1,2,4-Thiadiazole Derivatives | KATAYAMA SEIYAKUSYO CO. Ltd. (JP) | 1993-04-14 | — | — | EP | disclosed |