Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562498 | 0.85 | STK4 (0.45) | PDE4BSTK4MAPTNPSR1TP53 | |
| SCHEMBL8561277 | 0.84 | PDE4B (0.61) | PDE4BMAPTNPSR1TP53ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8563873 | 0.83 | PDE4B (0.60) | PDE4BMAPTNPSR1TP53ALDH1A1 | |
| SCHEMBL8561203 | 0.82 | GAA (0.49) | PDE4BMAPTNPSR1PDE4DALDH1A1 | |
| SCHEMBL8567066 | 0.76 | MAPT (0.40) | STK4MAPTNPSR1TP53KDM4E | |
| SCHEMBL8329045 | 0.72 | MAPT (0.53) | PDE4BMAPTNPSR1TP53ALDH1A1 | |
| SCHEMBL8325585 | 0.72 | MAPT (0.56) | PDE4BMAPTNPSR1TP53ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8331150 | 0.71 | MAPT (0.52) | PDE4BMAPTNPSR1TP53KDM4E | |
| SCHEMBL8563378 | 0.71 | PDE4B (0.59) | PDE4BMAPTNPSR1TP53ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8327776 | 0.71 | MAPT (0.54) | PDE4BMAPTNPSR1TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | claimed |