Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 11/20 | 0.48 |
| ▸ | HTR3B | O95264 | 11/20 | 0.48 |
| ▸ | HTR3A | P46098 | 11/20 | 0.48 |
| ▸ | HTR3D | Q70Z44 | 11/20 | 0.48 |
| ▸ | HTR3C | Q8WXA8 | 11/20 | 0.48 |
| ▸ | HTR2C | P28335 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569105 | 0.90 | DRD2 (0.52) | HTR1AHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8571687 | 0.88 | HTR1A (0.49) | HTR1AMAPK1HTR3EHTR3BHTR3A | |
| SCHEMBL8565549 | 0.87 | MAPK1 (0.60) | HTR1AMAPK1HTR3EHTR3BHTR3A | |
| SCHEMBL8570061 | 0.84 | HTR1A (0.54) | HTR1AMAPK1HTR3EHTR3BHTR3A | |
| SCHEMBL8879183 | 0.80 | KDM4E (0.52) | HTR1AHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8565014 | 0.79 | HTR1A (0.48) | HTR1AMAPK1HTR3EHTR3BHTR3A | |
| SCHEMBL8572082 | 0.79 | HTR3E (0.41) | HTR1AHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8566284 | 0.78 | DRD4 (0.54) | HTR1AHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8564628 | 0.77 | ADRB1 (0.50) | HTR1AHTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL8565075 | 0.77 | DRD4 (0.53) | HTR1AMAPK1KDM4EDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623620-B1 | 5-HT3 Pyrrolopyrazine derivatives | ADIR (FR) | 1998-09-09 | — | — | EP | disclosed |
| US-5599812-A | ANTISEROTONINE AGENTS | ADIR ET COMPAGNIE (FR) | 1997-02-04 | — | — | US | disclosed |