SCHEMBL8567950

SCHEMBL8567950

Nc1nc2ccccc2c([N+](=O)[O-])c1[N+](=O)[O-]

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.47
ALDH1A1 P00352 5/20 0.46
MAPT P10636 7/20 0.46
MGMT P16455 1/20 0.46
DCPS Q96C86 1/20 0.44
KDM4E B2RXH2 4/20 0.44
HPGD P15428 4/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
HSD17B10 Q99714 3/20 0.44
GLA P06280 3/20 0.44
TDP1 Q9NUW8 2/20 0.44
CASP1 P29466 2/20 0.44
CASP7 P55210 2/20 0.44
CHRM2 P08172 1/20 0.44
ADRA2A P08913 1/20 0.44
ADORA3 P0DMS8 1/20 0.44
CHRM1 P11229 1/20 0.44
NQO2 P16083 1/20 0.44
MAOA P21397 1/20 0.44
DRD1 P21728 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3953291 0.88 KDM4E (0.52) CYP3A4ALDH1A1MAPTMGMTDCPS
SCHEMBL8564301 0.88 KDM4E (0.47) CYP3A4ALDH1A1MAPTMGMTDCPS
SCHEMBL12518927 0.85 MAOA (0.48) CYP3A4ALDH1A1MAPTMGMTDCPS
SCHEMBL8562456 0.85 CYP3A4 (0.43) CYP3A4ALDH1A1MAPTMGMTDCPS
SCHEMBL8567514 0.85 S100A4 (0.54) CYP3A4ALDH1A1MAPTMGMTDCPS
SCHEMBL20291524 0.83 CYP3A4 (0.61) CYP3A4ALDH1A1MAPTKDM4EHPGD
SCHEMBL8568375 0.82 PDE10A (0.46) CYP3A4ALDH1A1MAPTMGMTHSD17B10
SCHEMBL8566816 0.81 MAPT (0.43) CYP3A4ALDH1A1MAPTMGMTDCPS
SCHEMBL8564469 0.81 ALDH1A1 (0.53) CYP3A4ALDH1A1MAPTMGMTDCPS
SCHEMBL8567025 0.81 MAPT (0.43) CYP3A4ALDH1A1MAPTMGMTDCPS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0735025-B1 Process for producing aminonitropyridines SUMITOMO CHEMICAL CO (JP) 1998-07-01 EP disclosed
US-5648496-A AMINATION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-07-15 US disclosed
EP-0735025-A1 Process for producing aminonitropyridines SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-10-02 EP disclosed