SCHEMBL8568181

SCHEMBL8568181

Fc1cc2[nH]nnc2cc1Cl

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.52
ALDH1A1 P00352 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
MAPK13 O15264 1/20 0.37
CDK1 P06493 1/20 0.37
PIM1 P11309 1/20 0.37
DYRK1A Q13627 1/20 0.37
PIM3 Q86V86 1/20 0.37
CLK4 Q9HAZ1 1/20 0.37
TXN P10599 1/20 0.36
ALPL P05186 7/20 0.35
EGLN1 Q9GZT9 1/20 0.34
PDE10A Q9Y233 1/20 0.34
GPR84 Q9NQS5 1/20 0.33
GRM4 Q14833 1/20 0.31
EGFR P00533 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28695956 0.92 MAPT (0.43) MAPTALDH1A1TDP1MAPK13CDK1
SCHEMBL7855617 0.83 MAPT (0.39) MAPTALDH1A1TDP1
SCHEMBL102964 0.83 KDM4E (0.35) MAPTALDH1A1GPR84
SCHEMBL205009 0.83 MAPK13 (0.48) MAPTALDH1A1MAPK13CDK1PIM1
SCHEMBL14730924 0.78
SCHEMBL1021150 0.78 GRIN2D (0.44) ALDH1A1MAPK13CDK1PIM1DYRK1A
SCHEMBL9307669 0.76 MAPK13 (0.37) MAPK13CDK1PIM1DYRK1APIM3
SCHEMBL12180644 0.76 MAPT (0.35) MAPTALDH1A1TDP1
SCHEMBL2589396 0.76 EGLN1 (0.34) EGLN1
SCHEMBL26449991 0.76 DAO (0.35) MAPTTDP1EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240174583-A1 PROCESSES FOR THE VAPOR PHASE HYDROGENATION OF ALDEHYDES DOW TECHNOLOGY INVESTMENTS LLC (US) 2024-05-30 US disclosed
EP-4347544-A1 PROCESSES FOR THE VAPOR PHASE HYDROGENATION OF ALDEHYDES Dow Technology Investments LLC (US) 2024-04-10 EP disclosed
CN-117242047-A Process for the vapor phase hydrogenation of aldehydes 陶氏技术投资有限责任公司 2023-12-15 CN disclosed
WO-2022250790-A1 PROCESSES FOR THE VAPOR PHASE HYDROGENATION OF ALDEHYDES DOW TECHNOLOGY INVESTMENTS LLC (US) 2022-12-01 WO disclosed
US-9573870-B2 Hetereocyclic agent as catalytic stabilizing agent in a hydroformylation process DOW TECHNOLOGY INVESTMENTS LLC (US) 2017-02-21 US disclosed
US-20150376101-A1 HETEREOCYCLIC AGENT AS CATALYTIC STABILIZING AGENT IN A HYDROFORMYLATION PROCESS UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY LLC 2015-12-31 US disclosed
EP-0873292-A1 IMPROVED METAL-LIGAND COMPLEX CATALYZED PROCESSES UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION (US) 1998-10-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150376101-A1 HETEREOCYCLIC AGENT AS CATALYTIC STABILIZING AGENT IN A HYDROFORMYLATION PROCESS NUDT1, CAT, HRAS MAPT 4148/4885ALDH1A1 1425/4885TDP1 2238/4885
US-20240174583-A1 PROCESSES FOR THE VAPOR PHASE HYDROGENATION OF ALDEHYDES ADH1C, ADH5, ALDH2 MAPT 1565/4885ALDH1A1 7/4885TDP1 1008/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.