Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 4/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 7/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564079 | 0.91 | CTSS (0.38) | CTSSCTSLCTSKITGB3ITGA2B | |
| SCHEMBL8561162 | 0.88 | CTSS (0.41) | CTSSCTSLCTSKEPHX1ACHE | |
| SCHEMBL16119729 | 0.85 | CTSS (0.47) | CTSSCTSLCTSKEPHX1ACHE | |
| SCHEMBL1895877 | 0.85 | CYP1A2 (0.40) | EPHX1ACHEITGB3ITGA2BALDH1A1 | |
| SCHEMBL3645507 | 0.84 | MMP3 (0.40) | EPHX1ACHEITGB3ITGA2BALDH1A1 | |
| SCHEMBL480292 | 0.82 | EPHX1 (0.46) | CTSKEPHX1ACHEITGB3ITGA2B | |
| SCHEMBL284168 | 0.82 | EPHX1 (0.46) | CTSKEPHX1ACHEITGB3ITGA2B | |
| Water SCHEMBL27304038 | 0.81 | PLA2G2A (0.54) | ALDH1A1 | |
| SCHEMBL21359118 | 0.81 | HRH3 (0.42) | EPHX1ACHENPC1HPGDRAB9A | |
| Water SCHEMBL4794958 | 0.81 | PLA2G2A (0.54) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821675-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-02-04 | — | — | EP | disclosed |
| US-5703092-A | TREATING ARTHRITIS, OTHER INFLAMMATORY DISEASES MEDIATED BY MATRIX METALLOPROTEINASE AND/OR TUMOR NECROSIS FACTOR | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1997-12-30 | — | — | US | disclosed |
| WO-1996033176-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-10-24 | — | — | WO | disclosed |