Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 7/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569656 | 0.84 | CTSS (0.43) | EPHX1ACHEITGB3ITGA2BALDH1A1 | |
| SCHEMBL1895877 | 0.84 | CYP1A2 (0.40) | EPHX1ACHEITGB3ITGA2BALDH1A1 | |
| SCHEMBL2332506 | 0.83 | TGFBR1 (0.47) | EPHX1ACHEALDH1A1 | |
| SCHEMBL1840799 | 0.83 | TGFBR1 (0.47) | EPHX1ACHEALDH1A1 | |
| SCHEMBL5765667 | 0.83 | TGFBR1 (0.47) | EPHX1ACHEALDH1A1 | |
| SCHEMBL480292 | 0.81 | EPHX1 (0.46) | EPHX1ACHEITGB3ITGA2BALDH1A1 | |
| SCHEMBL284168 | 0.81 | EPHX1 (0.46) | EPHX1ACHEITGB3ITGA2BALDH1A1 | |
| SCHEMBL284211 | 0.80 | ITGB3 (0.46) | EPHX1ACHEITGB3ITGA2BALDH1A1 | |
| SCHEMBL3655323 | 0.80 | ITGB3 (0.46) | EPHX1ACHEITGB3ITGA2BALDH1A1 | |
| SCHEMBL283288 | 0.80 | ITGB3 (0.46) | EPHX1ACHEITGB3ITGA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173724-A2 | QUINAZOLINONE COMPOUNDS AND METHODS OF USE THEREOF | ArQule, Inc. (US) | 2010-04-14 | — | — | EP | disclosed |
| WO-2009002808-A2 | QUINAZOLINONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. (US) | 2008-12-31 | — | — | WO | disclosed |