Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 3/20 | 0.53 |
| ▸ | CYCS | P99999 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16912677 | 0.87 | TOP1 (0.54) | TOP1CYCSMEN1MAPTKMT2A | |
| SCHEMBL16923748 | 0.87 | ALDH1A1 (0.55) | TOP1CYCSMEN1MAPTKMT2A | |
| SCHEMBL16920374 | 0.84 | SMN1; SMN2 (0.54) | TOP1CYCSABCG2 | |
| SCHEMBL9018611 | 0.82 | TOP1 (0.52) | TOP1CYCSL3MBTL1MEN1KMT2A | |
| SCHEMBL2403632 | 0.80 | TOP1 (0.54) | TOP1CYCSMAPTABCG2 | |
| SCHEMBL13609844 | 0.79 | TOP1 (0.53) | TOP1CYCSMEN1MAPTKMT2A | |
| SCHEMBL16923657 | 0.79 | MEN1 (0.53) | TOP1CYCSMEN1KMT2A | |
| SCHEMBL9287004 | 0.77 | TOP1 (0.53) | TOP1CYCSABCG2 | |
| SCHEMBL2125691 | 0.77 | JAK3 (0.53) | TOP1CYCSL3MBTL1MEN1MAPT | |
| SCHEMBL8994447 | 0.77 | TOP1 (0.60) | TOP1CYCSL3MBTL1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5853713-A | Biologically compatible linear block copolymers of polyalkylene oxide and peptide units | STERLING WINTHROP INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5618528-A | Biologically compatible linear block copolymers of polyalkylene oxide and peptide units | STERLING WINTHROP INC. (US) | 1997-04-08 | — | — | US | disclosed |
| EP-0748226-A1 | BLOCK COPOLYMERS | NYCOMED IMAGING AS (NO) | 1996-12-18 | — | — | EP | disclosed |
| WO-1995022991-A2 | BLOCK COPOLYMERS | NYCOMED IMAGING AS (NO) | 1995-08-31 | — | — | WO | disclosed |