Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31453688 | 0.77 | KMT2A (0.59) | MAPKAPK2KMT2AALDH1A1MEN1TRPA1 | |
| SCHEMBL9008342 | 0.77 | KMT2A (0.59) | MAPKAPK2KMT2AALDH1A1MEN1TRPA1 | |
| SCHEMBL1704674 | 0.73 | KDM1A (0.53) | MAPKAPK2KDM1AMAOBSMN1; SMN2HTR6 | |
| SCHEMBL6213417 | 0.71 | P2RX7 (0.49) | MAPKAPK2KMT2AMEN1TRPA1MAPT | |
| SCHEMBL8572372 | 0.70 | KMT2A (0.40) | MAPKAPK2KMT2AALDH1A1MEN1TRPA1 | |
| SCHEMBL6559446 | 0.70 | KDM1A (0.47) | KDM1AMAOBSMN1; SMN2HTR6 | |
| SCHEMBL6559451 | 0.70 | KDM1A (0.47) | KDM1AMAOBSMN1; SMN2HTR6 | |
| SCHEMBL8574078 | 0.70 | MAPKAPK2 (0.42) | MAPKAPK2KMT2AALDH1A1MEN1TRPA1 | |
| SCHEMBL8577356 | 0.70 | ALDH1A1 (0.40) | MAPKAPK2KMT2AALDH1A1MEN1TRPA1 | |
| SCHEMBL21460294 | 0.69 | SLC6A2 (0.44) | KMT2AMEN1MAPTHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821240-A | ENZYME INHIBITORS, SIGNAL INHIBITORS FOR ANTIINFLAMMATORY AGENTS, ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS AND HORMONE INHIBITORS | DR. KARL THOMAE GMBH (DE) | 1998-10-13 | — | — | US | disclosed |