Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.53 |
| ▸ | DRD4 | P21917 | 7/20 | 0.53 |
| ▸ | DRD3 | P35462 | 7/20 | 0.53 |
| ▸ | ACHE | P22303 | 4/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8570890 | 0.92 | HTR2A (0.48) | DRD2DRD4DRD3ACHEBCHE | |
| Maleic Acid SCHEMBL8570886 | 0.92 | HTR2A (0.48) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL13490648 | 0.74 | DRD2 (0.60) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL13490463 | 0.72 | DRD2 (0.51) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL28425145 | 0.71 | DRD2 (0.65) | DRD2DRD4ACHEBCHEMEN1 | |
| SCHEMBL13490557 | 0.70 | DRD2 (0.59) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL6980499 | 0.70 | DRD2 (0.67) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL6975763 | 0.70 | DRD2 (0.86) | DRD2DRD4DRD3ACHEBCHE | |
| SCHEMBL6195713 | 0.69 | DRD4 (0.59) | DRD2DRD4DRD3ACHEMEN1 | |
| SCHEMBL11499121 | 0.69 | MEN1 (0.68) | DRD2DRD4ACHEPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750542-A | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors | PFIZER (US) | 1998-05-12 | — | — | US | disclosed |