Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 9/20 | 0.48 |
| ▸ | HTR2C known ✓ | P28335 | 9/20 | 0.48 |
| ▸ | HTR2B known ✓ | P41595 | 9/20 | 0.48 |
| ▸ | DRD2 known ✓ | P14416 | 7/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8570890 | 1.00 | HTR2A (0.48) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| SCHEMBL8575247 | 0.92 | DRD2 (0.53) | HTR2ADRD2DRD4DRD3BCHE | |
| Fumaric Acid SCHEMBL8575266 | 0.76 | HTR2A (0.46) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| Fumaric Acid SCHEMBL8569611 | 0.72 | HTR2A (0.46) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| Maleic Acid SCHEMBL8569609 | 0.72 | HTR2A (0.46) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| Maleic Acid SCHEMBL6986260 | 0.71 | ACHE (0.84) | DRD2DRD4DRD3BCHEACHE | |
| Fumaric Acid SCHEMBL6986264 | 0.71 | ACHE (0.84) | DRD2DRD4DRD3BCHEACHE | |
| Maleic Acid SCHEMBL8574182 | 0.71 | ACHE (0.49) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| Fumaric Acid SCHEMBL8572755 | 0.71 | ACHE (0.45) | HTR2AHTR2CHTR2BSIGMAR1DRD2 | |
| Fumaric Acid SCHEMBL8574186 | 0.71 | ACHE (0.49) | HTR2AHTR2CHTR2BSIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5750542-A | Benzisoxazole and benzisothizole derivatives as cholinesterase inhibitors | PFIZER (US) | 1998-05-12 | — | — | US | disclosed |