Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.49 |
| ▸ | HTR2A | P28223 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 9/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 6/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299572 | 0.96 | HSD11B1 (0.45) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8301506 | 0.90 | HSD11B1 (0.51) | DRD2SLC6A4HTR1DHSD11B1OPRM1 | |
| SCHEMBL27492957 | 0.90 | ADRA1D (0.53) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8296911 | 0.87 | ADRA1D (0.55) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8296056 | 0.86 | ADRA1D (0.48) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8303863 | 0.85 | RORC (0.48) | DRD2HTR2AHTR7KCNH2SLC6A4 | |
| SCHEMBL27524757 | 0.83 | HTR1D (0.49) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8296250 | 0.82 | HSD11B1 (0.62) | ADRA1DDRD2HTR2AHTR7KCNH2 | |
| SCHEMBL8302073 | 0.82 | SLC6A4 (0.46) | KCNH2SLC6A4HSD11B1 | |
| SCHEMBL8435995 | 0.81 | ADRA1D (0.46) | ADRA1DDRD2HTR2AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1223650-A | Piperidines and pyrrolidines | MERCK PATENT GMBH (DE) | 1999-07-21 | — | — | CN | disclosed |
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |