Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303863 | 0.96 | RORC (0.48) | SLC6A4RORCACHESLC6A2SLC6A3 | |
| SCHEMBL8301506 | 0.92 | HSD11B1 (0.51) | SLC6A4RORCHSD11B1 | |
| SCHEMBL8299533 | 0.88 | HSD11B1 (0.60) | SLC6A4ACHEHSD11B1HTR6 | |
| SCHEMBL8299572 | 0.86 | HSD11B1 (0.45) | SLC6A4RORCHSD11B1KCNH2 | |
| SCHEMBL8304245 | 0.83 | OPRM1 (0.56) | SLC6A4HSD11B1KCNH2HTR6 | |
| SCHEMBL8296250 | 0.82 | HSD11B1 (0.62) | SLC6A4HSD11B1KCNH2HTR6 | |
| SCHEMBL8575896 | 0.82 | ADRA1D (0.50) | SLC6A4HSD11B1KCNH2 | |
| SCHEMBL8296768 | 0.82 | HSD11B1 (0.48) | SLC6A4HSD11B1KCNH2HTR6 | |
| SCHEMBL27524757 | 0.77 | HTR1D (0.49) | SLC6A4KCNH2 | |
| SCHEMBL8296911 | 0.77 | ADRA1D (0.55) | SLC6A4HSD11B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |