Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5823399 | 0.86 | CTNNB1 (0.57) | SMN1; SMN2LMNAMAPTRAB9ANPC1 | |
| SCHEMBL22230088 | 0.84 | MAPT (0.56) | SMN1; SMN2LMNAMAPTRAB9ANPC1 | |
| SCHEMBL22230026 | 0.82 | MAPT (0.55) | SMN1; SMN2LMNAMAPTRAB9ANPC1 | |
| SCHEMBL3522633 | 0.78 | MAPT (0.60) | SMN1; SMN2LMNAMAPTRAB9ANPC1 | |
| SCHEMBL984344 | 0.76 | MAOB (0.62) | SMN1; SMN2LMNATSHRMAPTRAB9A | |
| SCHEMBL8301109 | 0.74 | RAB9A (0.61) | SMN1; SMN2LMNAMAPTRAB9ANPC1 | |
| SCHEMBL21834006 | 0.73 | ALDH1A1 (0.66) | SMN1; SMN2LMNAMAPTRAB9ANPC1 | |
| SCHEMBL21833994 | 0.73 | ALDH1A1 (0.56) | SMN1; SMN2LMNAMAPTRAB9ANPC1 | |
| SCHEMBL8525053 | 0.72 | RAB9A (0.48) | SMN1; SMN2LMNAMAPTRAB9ANPC1 | |
| SCHEMBL28471046 | 0.72 | MAPT (0.65) | SMN1; SMN2LMNATSHRMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731321-A | Endothelin receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-03-24 | — | — | US | disclosed |
| EP-0757039-A1 | Endothelin receptor antagonists | MERCK PATENT GmbH (DE) | 1997-02-05 | — | — | EP | disclosed |