SCHEMBL8577285

SCHEMBL8577285

CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)OC1CC(=O)NC1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSL P07711 2/20 0.46
CTSB P07858 1/20 0.44
CTSS P25774 1/20 0.44
CTSK P43235 1/20 0.44
GAA P10253 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
CAPN1 P07384 1/20 0.40
IDO1 P14902 1/20 0.40
POLB P06746 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
AAK1 Q2M2I8 1/20 0.39
MAPK1 P28482 1/20 0.38
MAP1LC3B Q9GZQ8 1/20 0.38
MAP1LC3A Q9H492 1/20 0.38
ALDH1A1 P00352 2/20 0.38
LMNA P02545 1/20 0.38
MEN1 O00255 1/20 0.38
MAPT P10636 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10631067 1.00 CTSL (0.46) CTSLCTSBCTSSCTSKGAA
SCHEMBL8695509 0.88 IDO1 (0.41) CTSLCTSSCTSKGAAL3MBTL1
SCHEMBL9228941 0.86 IDO1 (0.40) CTSLCTSBCTSSCTSKGAA
SCHEMBL5707315 0.85 CAPN1 (0.41) CTSLCTSBCTSSCTSKCAPN1
SCHEMBL10631140 0.84 NAAA (0.38) CTSLCTSBCTSSCTSKL3MBTL1
SCHEMBL8576306 0.84 EPHX2 (0.42) CTSLGAAIDO1TDP1ALDH1A1
SCHEMBL10633587 0.84 EPHX2 (0.42) CTSLGAAIDO1TDP1ALDH1A1
SCHEMBL8574646 0.82 CTSK (0.40) CTSLCTSBCTSSCTSKGAA
SCHEMBL7705336 0.81 EPHX2 (0.53) CTSLCTSBCTSSCTSKIDO1
SCHEMBL3870531 0.81 EPHX2 (0.53) CTSLCTSBCTSSCTSKIDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5789386-A WATER SOLUBLE ANTITUMOR AGENTS; INJECTABLE ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI (JP) 1998-08-04 US disclosed