SCHEMBL8579683

SCHEMBL8579683

CCCc1ccc(Oc2ccc(N)cc2)c(C(C)CC)c1

nearest known ligand 0.52

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ACACB O00763 4/20 0.42
CYP19A1 P11511 1/20 0.40
ALDH1A1 P00352 1/20 0.39
RAB9A P51151 1/20 0.39
TAAR5 O14804 1/20 0.37
TAAR1 Q96RJ0 1/20 0.37
TSHR P16473 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8579754 0.89 ACACB (0.44) ACACBCYP19A1ALDH1A1RAB9ATAAR5
SCHEMBL8153194 0.89 TDP1 (0.39) CYP19A1ALDH1A1RAB9ATSHRTDP1
SCHEMBL8580831 0.89 TSHR (0.39) CYP19A1ALDH1A1RAB9ATSHRTDP1
SCHEMBL17660080 0.82 TDP1 (0.46) ALDH1A1RAB9ATSHRTDP1MAPT
SCHEMBL8157894 0.81 TDP1 (0.39) ALDH1A1RAB9ATSHRTDP1MAPT
SCHEMBL8406583 0.79 MGLL (0.53) ACACBALDH1A1TDP1
SCHEMBL8581639 0.79 TSHR (0.47) ACACBCYP19A1ALDH1A1RAB9ATAAR5
SCHEMBL8415231 0.79 CYP19A1 (0.45) ACACBCYP19A1ALDH1A1RAB9ATAAR5
SCHEMBL8581645 0.79 CYP19A1 (0.45) ACACBCYP19A1ALDH1A1RAB9ATAAR5
SCHEMBL7613145 0.78 RORC (0.52) ALDH1A1RAB9ATSHRTDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5744203-A POLYMER MIXTURES OF POLYURETHANES, POLYESTERS, POLYIMIDES, POLYCARBONATES AND POLYUREAS HOECHST AKTIENGESELLSCHAFT (DE) 1998-04-28 US disclosed
US-5670084-A Alignment layer material for liquid crystal display devices HOECHST AKTIENGESELLSCHAFT (DE) 1997-09-23 US disclosed