SCHEMBL8580205

SCHEMBL8580205

C=CC(=O)Oc1occc1C

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
THRB P10828 5/20 0.40
THRA P10827 1/20 0.34
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
TYMS P04818 1/20 0.33
MEN1 O00255 1/20 0.31
NPC1 O15118 1/20 0.31
PKM P14618 1/20 0.31
RAB9A P51151 1/20 0.31
KMT2A Q03164 1/20 0.31
TGM2 P21980 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27571612 0.77 LMNA (0.42) THRBKDM4EALDH1A1MAPTPKM
SCHEMBL29211182 0.76 THRB (0.53) THRBTHRAALDH1A1TYMSMEN1
SCHEMBL6224785 0.74 KDM4E (0.39) THRBKDM4EALDH1A1MAPTMEN1
SCHEMBL8582686 0.73 THRB (0.52) THRBTHRAALDH1A1TYMSMEN1
SCHEMBL27501516 0.73 ACHE (0.41) THRBKDM4EALDH1A1MAPTKMT2A
SCHEMBL11667564 0.70 THRB (0.37) THRBTHRAALDH1A1TYMS
Acrylic Acid SCHEMBL28574693 0.68 LMNA (0.40) THRBKDM4EALDH1A1MAPTMEN1
SCHEMBL25565205 0.68 L3MBTL1 (0.47) THRBTHRAKDM4EALDH1A1TYMS
SCHEMBL8665364 0.68 TYMS (0.38) THRBTHRATYMS
SCHEMBL17708232 0.67 THRB (0.42) THRBTHRAALDH1A1TYMSPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5756569-A FOR POLYMERS EASTMAN CHEMICAL COMPANY 1998-05-26 US claimed
US-5716603-A QUICK-SETTING; WEAR RESISTANCE; GLOSS EASTMAN CHEMICAL COMPANY (US) 1998-02-10 US claimed
WO-1997000664-A1 AQUEOUS NAIL POLISH COMPOSITIONS CONTAINING ACRYLIC RESINS CROSSLINKED WITH ACRYLATED URETHANE OLIGOMERS EASTMAN CHEMICAL COMPANY (US) 1997-01-09 WO claimed
US-5756569-A FOR POLYMERS EASTMAN CHEMICAL COMPANY 1998-05-26 US disclosed
US-5756168-A Laminate article and method for making same EASTMAN CHEMICAL COMPANY 1998-05-26 US disclosed
US-5716603-A QUICK-SETTING; WEAR RESISTANCE; GLOSS EASTMAN CHEMICAL COMPANY (US) 1998-02-10 US disclosed
WO-1997033749-A1 COMPOSITE STRUCTURE HAVING A POROUS SURFACE AND A MULTILAYER FILM LAMINATED THERETO EASTMAN CHEMICAL COMPANY (US) 1997-09-18 WO disclosed
WO-1997031982-A1 THE USE OF ALKYL 3-ALKOXYPROPIONATES AS COALESCING AGENTS IN AQUEOUS COATING COMPOSITIONS EASTMAN CHEMICAL COMPANY (US) 1997-09-04 WO disclosed
WO-1997000664-A1 AQUEOUS NAIL POLISH COMPOSITIONS CONTAINING ACRYLIC RESINS CROSSLINKED WITH ACRYLATED URETHANE OLIGOMERS EASTMAN CHEMICAL COMPANY (US) 1997-01-09 WO disclosed
US-4158053-A COMPRISING ACRYLIC ESTER AND AROMATIC OLEFIN POLYMERS, QUICK-DRYING, NON-YELLOWING, NON-FLAMMABLE ELI LILLY AND COMPANY (US) 1979-06-12 US disclosed
EP-0000819-A1 Nail coating formulation ELI LILLY AND COMPANY (US) 1979-02-21 EP disclosed