Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 5/20 | 0.39 |
| ▸ | ERN1 | O75460 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 5/20 | 0.33 |
| ▸ | ATF1 | P18846 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23624330 | 0.81 | ALDH1A1 (0.40) | ALDH1A1GAAPOLBCASP6KDM4E | |
| SCHEMBL1904655 | 0.79 | QPCT (0.39) | ALDH1A1GAAKDM4EERN1TSHR | |
| SCHEMBL13736042 | 0.78 | NUDT1 (0.39) | ALDH1A1KDM4ETSHRTDP1CYP1A2 | |
| SCHEMBL5677080 | 0.76 | JUN (0.42) | ALDH1A1GAAPOLBCASP6KDM4E | |
| SCHEMBL26635312 | 0.76 | ALDH1A1 (0.43) | ALDH1A1GAAPOLBCASP6KDM4E | |
| SCHEMBL30540239 | 0.76 | ALDH1A1 (0.43) | ALDH1A1GAAPOLBCASP6KDM4E | |
| SCHEMBL28303673 | 0.75 | ALDH1A1 (0.32) | ALDH1A1GAAKDM4EERN1TSHR | |
| SCHEMBL25527232 | 0.75 | KDM4E (0.36) | ALDH1A1KDM4ETSHRTDP1 | |
| SCHEMBL342595 | 0.74 | CYP1A2 (0.40) | ALDH1A1GAAPOLBCASP6KDM4E | |
| SCHEMBL1981633 | 0.74 | ALDH1A1 (0.46) | ALDH1A1GAAPOLBCASP6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4045036-B1 | HETEROARYL-BIPHENYL AMIDES FOR THE TREATMENT OF PD-L1 DISEASES | CHEMOCENTRYX INC (US) | 2026-03-04 | — | — | EP | disclosed |
| US-12497383-B2 | Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases | CHEMOCENTRYX, INC. (US) | 2025-12-16 | — | — | US | disclosed |
| US-20250361238-A1 | 1,4-DIPHENYL-1H-INDAZOLE AND 1-PYRIDIN-2-YL-4-PHENYL-1H-INDAZOLE DERIVATIVES AS PD-1/PD-L1 MODULATORS FOR THE TREATMENT OF CANCER | SOPONPONG JAKAPUN (TH) | 2025-11-27 | — | — | US | disclosed |
| US-12428427-B2 | Methods and compositions for targeting PD-L1 | ALIGOS THERAPEUTICS, INC. (US) | 2025-09-30 | — | — | US | disclosed |
| US-20240277706-A1 | METHODS AND COMPOSTITIONS FOR TARGETING PD-L1 | ALIGOS THERAPEUTICS, INC. | 2024-08-22 | — | — | US | disclosed |
| WO-2023250335-A1 | 1,4-DIPHENYL-1 H-INDAZOLE AND 1-PYRIDIN-2-YL-4-PHENYL-1 H-INDAZOLE DERIVATIVES AS PD-1/PD-L1 MODULATORS FOR THE TREATMENT OF CANCER | CHULALONGKORN UNIVERSITY (TH) | 2023-12-28 | — | — | WO | disclosed |
| CN-113348170-B | Biphenyl derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2023-12-22 | — | — | CN | disclosed |
| US-20230322731-A1 | HETEROARYL-BIPHENYL AMIDES FOR THE TREATMENT OF PD-L1 DISEASES | CHEMOCENTRYX, INC. | 2023-10-12 | — | — | US | disclosed |
| US-11713307-B2 | Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases | CHEMOCENTRYX, INC. (US) | 2023-08-01 | — | — | US | disclosed |
| US-20230192713-A1 | METHODS AND COMPOSITIONS FOR TARGETING PD-L1 | ALIGOS THERAPEUTICS, INC. | 2023-06-22 | — | — | US | disclosed |
| EP-4086253-A1 | BIPHENYL DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2022-11-09 | — | — | EP | disclosed |
| EP-4045036-A1 | HETEROARYL-BIPHENYL AMIDES FOR THE TREATMENT OF PD-L1 DISEASES | ChemoCentryx, Inc. (US) | 2022-08-24 | — | — | EP | disclosed |
| CN-114585359-A | Heteroaryl benzidines for the treatment of PD-L1 diseases | 凯莫森特里克斯股份有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-113801111-A | Biphenyl derivative inhibitor and preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-12-17 | — | — | CN | disclosed |
| CN-113348170-A | Biphenyl derivative inhibitor, preparation method and application thereof | 上海翰森生物医药科技有限公司 | 2021-09-03 | — | — | CN | disclosed |
| WO-2021136354-A1 | BIPHENYL DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2021-07-08 | — | — | WO | disclosed |
| WO-2021136354-A1 | BIPHENYL DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海翰森生物医药科技有限公司 | 2021-07-08 | — | — | WO | disclosed |
| US-20210130325-A1 | HETEROARYL-BIPHENYL AMIDES FOR THE TREATMENT OF PD-L1 DISEASES | CHEMOCENTRYX, INC. | 2021-05-06 | — | — | US | disclosed |
| WO-2021076691-A1 | HETEROARYL-BIPHENYL AMIDES FOR THE TREATMENT OF PD-L1 DISEASES | CHEMOCENTRYX, INC. (US) | 2021-04-22 | — | — | WO | disclosed |
| US-5714438-A | PRE- AND POSTEMERGENCE HERBICIDES; BRAOADLEAF PLANTS AND GRASSES | ZENECA LIMITED (GB) | 1998-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12497383-B2 | Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases | CD274, PDCD1LG2, PDCD1 | ALDH1A1 463/4885GAA 1840/4885POLB 400/4885 |
| US-20240277706-A1 | METHODS AND COMPOSTITIONS FOR TARGETING PD-L1 | CD274, PDCD1, PDCD1LG2 | ALDH1A1 950/4885GAA 422/4885POLB 567/4885 |
| US-20230322731-A1 | HETEROARYL-BIPHENYL AMIDES FOR THE TREATMENT OF PD-L1 DISEASES | CD274, PDCD1LG2, PDCD1 | ALDH1A1 463/4885GAA 1840/4885POLB 400/4885 |
| US-20230192713-A1 | METHODS AND COMPOSITIONS FOR TARGETING PD-L1 | CD274, PDCD1LG2, PDCD1 | ALDH1A1 301/4885GAA 732/4885POLB 1642/4885 |
| US-11713307-B2 | Heteroaryl-biphenyl amides for the treatment of PD-L1 diseases | CD274, PDCD1LG2, PDCD1 | ALDH1A1 463/4885GAA 1840/4885POLB 400/4885 |
| US-20250361238-A1 | 1,4-DIPHENYL-1H-INDAZOLE AND 1-PYRIDIN-2-YL-4-PHENYL-1H-INDAZOLE DERIVATIVES AS PD-1/PD-L1 MODULATORS FOR THE TREATMENT OF CANCER | PDCD1, CD274, PDCD1LG2 | ALDH1A1 36/4885GAA 1574/4885POLB 1793/4885 |
| US-20210130325-A1 | HETEROARYL-BIPHENYL AMIDES FOR THE TREATMENT OF PD-L1 DISEASES | CD274, PDCD1LG2, PDCD1 | ALDH1A1 463/4885GAA 1840/4885POLB 400/4885 |
| US-12428427-B2 | Methods and compositions for targeting PD-L1 | CD274, PDCD1LG2, PDCD1 | ALDH1A1 301/4885GAA 732/4885POLB 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.