SCHEMBL8581981

SCHEMBL8581981

CCC(=O)Oc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1

nearest known ligand 0.66

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.63
LIPE Q05469 17/20 0.61
BCHE P06276 1/20 0.60
RAB9A P51151 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27396537 0.90 LMNA (0.60) LMNALIPEBCHERAB9A
SCHEMBL8740245 0.87 LMNA (0.60) LMNALIPEBCHERAB9A
SCHEMBL20626652 0.83 LIPE (0.67) LMNALIPEBCHERAB9A
SCHEMBL11668542 0.83 ESR1 (0.53)
SCHEMBL5647580 0.82 LIPE (0.65) LMNALIPEBCHERAB9A
SCHEMBL11194284 0.82 RAB9A (0.66) LMNALIPEBCHERAB9A
SCHEMBL1294868 0.81 KMT2A (0.58) LMNARAB9A
SCHEMBL11351938 0.81 MAPT (0.69) LMNALIPEBCHERAB9A
SCHEMBL5648472 0.81 LIPE (0.72) LMNALIPEBCHE
SCHEMBL9255996 0.80 MAPK1 (0.74) LMNALIPEBCHERAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5767107-A ADMINISTERING FRAGRANCES, FLAVORS, VITAMINS, AGRICULTURAL CHEMICALS AND DRUGS; BIODEGRADATION; TIME-RELEASE AGENTS BASF CORPORATION (US) 1998-06-16 US disclosed
US-5756719-A Double emulsion techniques for making novel compositions containing gluten and polysaccharides that contain uronic acid residues useful for encapsulating fats, oils and solids BASF CORPORATION (US) 1998-05-26 US disclosed
US-5675017-A REACTING VINY ETHER DERIVATIVE WITH HYDRZINE OR SUBSTITUTED HYDRAZINE TO FORM A CHEMICAL INTERMEDIATE, REACTING INTERMEDIATE WITH SUBSTITUTED HALIDE OR DIALKYL SULFATE MONSANTO COMPANY (US) 1997-10-07 US disclosed
US-5672715-A Herbicidal substituted 3-aryl-pyrazoles MONSANTO COMPANY (US) 1997-09-30 US disclosed
EP-0040478-A1 Process for preparing pyridine derivatives and intermediates useful in the process IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1981-11-25 EP disclosed