SCHEMBL8583240

SCHEMBL8583240

COc1ccc(-c2c(C(=O)O)ccc3ccccc23)cc1C1(C)CCCCC1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 3/20 0.61
RARG P13631 3/20 0.61
RARA P10276 2/20 0.61
WDR5 P61964 1/20 0.45
MAPT P10636 2/20 0.40
DHODH Q02127 2/20 0.40
KDM4E B2RXH2 5/20 0.40
ALDH1A1 P00352 4/20 0.40
HPGD P15428 3/20 0.40
PDE10A Q9Y233 1/20 0.39
HSD17B10 Q99714 1/20 0.39
NPSR1 Q6W5P4 2/20 0.39
PTGDR Q13258 1/20 0.39
PTGDR2 Q9Y5Y4 1/20 0.39
CDC25B P30305 1/20 0.39
KMT2A Q03164 1/20 0.38
PTGES O14684 1/20 0.38
NPC1 O15118 1/20 0.38
LMNA P02545 1/20 0.38
NFKB1 P19838 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9848266 0.81 WDR5 (0.58) WDR5MAPTDHODHKDM4EALDH1A1
SCHEMBL4747624 0.80 RARB (0.61) RARBRARGRARAWDR5MAPT
SCHEMBL9857155 0.78 RARB (0.54) RARBRARGRARAWDR5KDM4E
SCHEMBL7928834 0.76 RARB (1.00) RARBRARGRARAMAPTKDM4E
SCHEMBL3132655 0.74 WDR5 (0.72) WDR5MAPTKDM4EALDH1A1HPGD
SCHEMBL8565216 0.72 WDR5 (0.47) RARBRARGRARAWDR5KDM4E
SCHEMBL8583241 0.72 RARB (0.47) RARBRARGRARAMAPTKDM4E
SCHEMBL27746158 0.72 WDR5 (0.52) WDR5DHODHKDM4EALDH1A1HPGD
SCHEMBL14150946 0.72 WDR5 (0.63) WDR5MAPTKDM4EALDH1A1HPGD
SCHEMBL7689383 0.72 RARB (0.77) RARBRARGRARANPSR1PTGDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5854292-A Stimulating the differentiation of preadipocytic cells and therapies based thereon CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-12-29 US claimed
US-5827897-A INSULIN-RESISTANCE IN A MAMMAL TREATED BY ADMINISTERING A SYNERGISTIC MIXTURE OF A RETINOID AND A FATTY ACID; ANTIDIABETIC AGENTS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-10-27 US claimed
US-5728739-A LIGANDS WITH AFFINITY FOR RETINOIC ACID RECEPTORS IN SYNERGISTIC COMBINATION WITH A FATTY ACID, TREATMENT OF DIABETES, CARDIOVASCULAR DISEASE, ATHEROSCLEROSIS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-03-17 US claimed
US-5854292-A Stimulating the differentiation of preadipocytic cells and therapies based thereon CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-12-29 US disclosed
US-5827897-A INSULIN-RESISTANCE IN A MAMMAL TREATED BY ADMINISTERING A SYNERGISTIC MIXTURE OF A RETINOID AND A FATTY ACID; ANTIDIABETIC AGENTS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-10-27 US disclosed
US-5728739-A LIGANDS WITH AFFINITY FOR RETINOIC ACID RECEPTORS IN SYNERGISTIC COMBINATION WITH A FATTY ACID, TREATMENT OF DIABETES, CARDIOVASCULAR DISEASE, ATHEROSCLEROSIS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-03-17 US disclosed