SCHEMBL8583241

SCHEMBL8583241

COc1ccc(-c2c(C(=O)O)c(C3(C)CCCCC3)cc3ccccc23)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RARB P10826 2/20 0.47
RARG P13631 2/20 0.47
RARA P10276 1/20 0.47
ALOX5 P09917 1/20 0.44
GPR84 Q9NQS5 1/20 0.44
CDC25B P30305 1/20 0.40
TDP1 Q9NUW8 2/20 0.40
KDM4E B2RXH2 3/20 0.39
MAPT P10636 3/20 0.39
ALDH1A1 P00352 2/20 0.39
HPGD P15428 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
RAB9A P51151 2/20 0.39
NPSR1 Q6W5P4 2/20 0.39
NPC1 O15118 1/20 0.39
LMNA P02545 1/20 0.39
NFKB1 P19838 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
ATM Q13315 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8322639 0.80 KMT2A (0.47) RARBRARGRARAALOX5GPR84
SCHEMBL29929549 0.80 KMT2A (0.47) RARBRARGRARAALOX5GPR84
SCHEMBL8583240 0.72 RARB (0.61) RARBRARGRARACDC25BKDM4E
SCHEMBL4788678 0.70 ALDH1A1 (0.53) GPR84CDC25BKDM4EMAPTALDH1A1
SCHEMBL8322293 0.70 RARB (0.43) RARBRARGRARATDP1KDM4E
SCHEMBL18762062 0.69 ALOX5 (0.58) ALOX5GPR84TDP1KDM4EMAPT
SCHEMBL29847407 0.69 ALOX5 (0.58) ALOX5GPR84TDP1KDM4EMAPT
SCHEMBL14150946 0.68 WDR5 (0.63) ALOX5GPR84CDC25BTDP1KDM4E
SCHEMBL8678216 0.68 HPGD (0.49) RARBRARGRARACDC25BKDM4E
SCHEMBL9639864 0.67 GFER (0.52) TDP1KDM4EMAPTALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5854292-A Stimulating the differentiation of preadipocytic cells and therapies based thereon CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-12-29 US claimed
US-5827897-A INSULIN-RESISTANCE IN A MAMMAL TREATED BY ADMINISTERING A SYNERGISTIC MIXTURE OF A RETINOID AND A FATTY ACID; ANTIDIABETIC AGENTS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-10-27 US claimed
US-5728739-A LIGANDS WITH AFFINITY FOR RETINOIC ACID RECEPTORS IN SYNERGISTIC COMBINATION WITH A FATTY ACID, TREATMENT OF DIABETES, CARDIOVASCULAR DISEASE, ATHEROSCLEROSIS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-03-17 US claimed
US-5854292-A Stimulating the differentiation of preadipocytic cells and therapies based thereon CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-12-29 US disclosed
US-5827897-A INSULIN-RESISTANCE IN A MAMMAL TREATED BY ADMINISTERING A SYNERGISTIC MIXTURE OF A RETINOID AND A FATTY ACID; ANTIDIABETIC AGENTS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-10-27 US disclosed
US-5728739-A LIGANDS WITH AFFINITY FOR RETINOIC ACID RECEPTORS IN SYNERGISTIC COMBINATION WITH A FATTY ACID, TREATMENT OF DIABETES, CARDIOVASCULAR DISEASE, ATHEROSCLEROSIS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-03-17 US disclosed