Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 2/20 | 0.48 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12133560 | 0.77 | MLYCD (0.72) | MLYCDTAAR1HDAC1HDAC6KMT2A | |
| SCHEMBL1006489 | 0.73 | NAMPT (0.54) | MLYCDHDAC1HDAC6KMT2AMEN1 | |
| SCHEMBL2762507 | 0.73 | LMNA (0.53) | HDAC1HDAC6KMT2AMEN1 | |
| SCHEMBL8092409 | 0.72 | HSD11B1 (0.47) | MLYCDHDAC1HDAC6RCE1OPRM1 | |
| SCHEMBL1926269 | 0.72 | HDAC1 (0.73) | HDAC1HDAC6RCE1KMT2AMEN1 | |
| SCHEMBL8863944 | 0.71 | MLYCD (0.60) | MLYCDHDAC6SIGMAR1KMT2AAOC3 | |
| SCHEMBL14219226 | 0.71 | MLYCD (0.49) | MLYCDTAAR1RCE1KMT2AAOC3 | |
| SCHEMBL13571678 | 0.71 | TP53 (0.52) | MLYCDHDAC1HDAC6KMT2A | |
| SCHEMBL1003735 | 0.71 | TP53 (0.68) | MLYCDHDAC1HDAC6OPRM1OPRD1 | |
| SCHEMBL1696479 | 0.71 | KMT2A (0.57) | MLYCDKMT2AOPRM1OPRD1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934264-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998012177-A1 | PYRROLIDINYL AND PYRROLINYL ETHYLAMINE COMPOUNDS AS KAPPA AGONISTS | PFIZER INC. (JP) | 1998-03-26 | — | — | WO | disclosed |