Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 5/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8590752 | 0.86 | TSHR (0.45) | CYP2D6CYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8589515 | 0.85 | CYP2D6 (0.46) | CYP2D6CYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8588407 | 0.83 | LTA4H (0.47) | CYP2D6CYP3A4ALDH1A1LMNAHTT | |
| SCHEMBL8590761 | 0.82 | MEN1 (0.50) | CYP2D6CYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8586519 | 0.81 | LMNA (0.47) | CYP2D6CYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8591111 | 0.81 | GAA (0.47) | CYP2D6CYP3A4ALDH1A1HPGDCYP1A2 | |
| SCHEMBL8587114 | 0.80 | PNMT (0.42) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL8586522 | 0.80 | LMNA (0.52) | CYP3A4MEN1ALDH1A1LMNAKMT2A | |
| SCHEMBL8587389 | 0.80 | ALDH1A1 (0.43) | CYP2D6CYP3A4SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8589339 | 0.78 | CYP1A2 (0.45) | CYP2D6CYP3A4CLK4ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998052890-A1 | 3-ARYLPROPYLAMINO NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1998-11-26 | — | — | WO | disclosed |