Sugi Predict

Sugi Predict / Compounds / SCHEMBL858858

SCHEMBL858858

SCHEMBL858858

S=C1N=c2ccccc2=N1

nearest known ligand 0.34

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ PKM P14618 1/20 0.34
▸ NPSR1 Q6W5P4 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ ALDH1A1 P00352 3/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ THRB P10828 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ CYP3A4 P08684 1/20 0.30
▸ PSMB8 P28062 1/20 0.30
▸ HSD17B10 Q99714 1/20 0.30
▸ TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21316061 0.72 MAPT (0.41) MAPTNPC1ALDH1A1MEN1KMT2A
SCHEMBL2033144 0.70 — —
SCHEMBL30417607 0.70 CYP1A2 (0.33) ALDH1A1
SCHEMBL4030876 0.68 CA3 (0.31) ALDH1A1
SCHEMBL11266186 0.67 KMT2A (0.36) ALDH1A1THRBKMT2AHSD17B10TDP1
SCHEMBL211306 0.67 TSHR (0.39) NPC1L3MBTL1ALDH1A1KMT2ATDP1
SCHEMBL3499657 0.67 CASP1 (0.39) MAPTNPC1L3MBTL1ALDH1A1MEN1
SCHEMBL1696827 0.67 ALDH1A1 (0.30) MAPTALDH1A1HSD17B10
SCHEMBL37950 0.67 MEN1 (0.35) MAPTNPC1PKMNPSR1L3MBTL1
SCHEMBL6094001 0.67 MAPT (0.30) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 669 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250214945-A1 THIOBENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND USE THEREOF KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2025-07-03 — — US claimed
US-20250214987-A1 THIOBENZIMIDAZOLE DERIVATIVE PREPARATION METHOD AND NOVEL INTERMEDIATE THEREFOR KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2025-07-03 — — US claimed
CN-119789670-A Perovskite solar cell and preparation method thereof 中建科工集团有限公司 2025-04-08 — — CN claimed
CN-119776919-A Preparation method of HVLP copper foil for improving seersucker defect, product and application thereof 九江德福科技股份有限公司 2025-04-08 — — CN claimed
WO-2025071191-A1 THIOBENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND USE THEREOF 고려대학교 산학협력단 2025-04-03 — — WO claimed
EP-4506346-A1 THIOBENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND USE THEREOF Korea University Research and Business Foundation (KR) 2025-02-12 — — EP claimed
EP-4501915-A1 THIOBENZIMIDAZOLE DERIVATIVE PREPARATION METHOD AND NOVEL INTERMEDIATE THEREFOR Korea University Research and Business Foundation (KR) 2025-02-05 — — EP claimed
CN-118974021-A Preparation method of thiobenzimidazole derivative and novel intermediate for same 高丽大学校产学协力团 2024-11-15 — — CN claimed
CN-118974041-A Thiobenzimidazole derivatives or pharmaceutically acceptable salts thereof and use thereof 高丽大学校产学协力团 2024-11-15 — — CN claimed
US-20230391753-A1 THIOBENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND USE THEREOF KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (KR) 2023-12-07 — — US claimed
EP-0518909-A1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE. HOECHST AG (DE) 1992-12-23 — — EP claimed
EP-0316649-B1 WATER INSOLUBLE AZO COLOURING AGENTS, THEIR PREPARATION AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1992-07-22 — — EP claimed
WO-1991013941-A1 WATER-INSOLUBLE AZO DYES, THEIR MANUFACTURE AND USE HOECHST AKTIENGESELLSCHAFT (DE) 1991-09-19 — — WO claimed
US-5026831-A Water-insoluble disazo colorants having hetero-bicyclic methylene-active compounds as coupling component HOECHST AKTIENGESELLSCHAFT (DE) 1991-06-25 — — US claimed
EP-0387086-A2 Photoinitiator compositions, photohardenable compositions containing the same THE MEAD CORPORATION (US) 1990-09-12 — — EP claimed
US-4954415-A Photoresists, photolithography THE MEAD CORPORATION (US) 1990-09-04 — — US claimed
EP-0384522-A1 Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones JANSSEN PHARMACEUTICA N.V. (BE) 1990-08-29 — — EP claimed
EP-0316649-A2 Water insoluble azo colouring agents, their preparation and use HOECHST AKTIENGESELLSCHAFT (DE) 1989-05-24 — — EP claimed
EP-0049656-B1 PURIFICATION DEVICE FOR REMOVING HEAVY METALS FROM CONTAMINATED AQUEOUS EFFLUENTS Commissariat à l'Energie Atomique (FR) 1985-05-29 — — EP claimed
US-4085090-A Aromatic polymers containing a nitrogen-containing ring group, and process for preparation thereof TEIJIN LIMITED (JA) 1978-04-18 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230391753-A1 THIOBENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND USE THEREOF TUBB3, TUBB, TUBB1 MAPT 149/4885NPC1 1991/4885PKM 1692/4885
US-20250214987-A1 THIOBENZIMIDAZOLE DERIVATIVE PREPARATION METHOD AND NOVEL INTERMEDIATE THEREFOR WEE1, WEE2, HADHB MAPT 4632/4885NPC1 3004/4885PKM 3233/4885
US-20250214945-A1 THIOBENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND USE THEREOF TTBK2, TUBB3, TUBB MAPT 157/4885NPC1 2913/4885PKM 2717/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.