Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.61 |
| ▸ | MMP8 | P22894 | 1/20 | 0.61 |
| ▸ | MMP14 | P50281 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ACP3 | P15309 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | LAP3 | P28838 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9652018 | 0.92 | MMP2 (0.64) | MMP2MMP8MMP14ALDH1A1MMP1 | |
| Diphenylsulfane SCHEMBL28287035 | 0.79 | HPGD (0.52) | ALDH1A1HPGDBCL2MCL1SRC | |
| SCHEMBL8855634 | 0.77 | SRC (0.67) | ALDH1A1HPGDBCL2MCL1SRC | |
| Tiludronic Acid SCHEMBL18988 | 0.76 | MMP2 (1.00) | MMP2MMP8MMP14HPGDMMP1 | |
| SCHEMBL8589347 | 0.76 | MMP2 (0.66) | MMP2MMP8MMP14ALDH1A1HPGD | |
| SCHEMBL2149971 | 0.76 | MMP2 (0.66) | MMP2MMP8MMP14ALDH1A1MMP1 | |
| SCHEMBL10788079 | 0.76 | MMP8 (0.66) | MMP2MMP8MMP14ALDH1A1HPGD | |
| SCHEMBL7761461 | 0.76 | MMP2 (0.55) | MMP2MMP8MMP14MMP1ACP3 | |
| Diphenylsulfane SCHEMBL9028896 | 0.74 | HPGD (0.54) | ALDH1A1HPGDBCL2MCL1SRC | |
| SCHEMBL2150897 | 0.74 | MMP2 (0.63) | MMP2MMP8MMP14ALDH1A1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0594857-B1 | METHANEDIPHOSPHONIC ACID DERIVATIVE, PRODUCTION THEREOF AND MEDICINAL USE THEREOF | TORAY INDUSTRIES (JP) | 1998-04-29 | — | — | EP | disclosed |
| US-5683992-A | TREATMENT OF RHEUMATISM, BONE DISORDERS, ANTIINFLAMMATORY, SUPPRESSION OF INTERLEUKIN-1, ANTIOXIDANT, TREATMENT OF AUTOIMMUNE DISEASES | TORAY INDUSTRIES, INC. (JP) | 1997-11-04 | — | — | US | disclosed |
| US-5527940-A | SUPPRESSES INTERLEUKIN-1 AND BONE DESTRUCTION DURING OSTEOPOROSIS; ANTIINFLAMMATORY AGENTS | TORAY INDUSTRIES, INC. (JP) | 1996-06-18 | — | — | US | disclosed |
| EP-0594857-A1 | METHANEDIPHOSPHONIC ACID DERIVATIVE, PRODUCTION THEREOF AND MEDICINAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1994-05-04 | — | — | EP | disclosed |