Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.37 |
| ▸ | DRD4 | P21917 | 4/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MTTP | P55157 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8666097 | 0.98 | DRD2 (0.36) | DRD2DRD4AKT1CHRM1CARM1 | |
| SCHEMBL8501237 | 0.94 | MTTP (0.36) | DRD2DRD4CHRM1KMT2APOLB | |
| SCHEMBL8501050 | 0.92 | MTTP (0.36) | DRD2DRD4CHRM1KMT2APOLB | |
| SCHEMBL8669688 | 0.91 | DRD2 (0.39) | DRD2DRD4AKT1CHRM1CARM1 | |
| SCHEMBL8664872 | 0.89 | SMPD2 (0.37) | POLBSMPD3 | |
| SCHEMBL8665519 | 0.89 | CCR3 (0.40) | DRD2 | |
| SCHEMBL8714745 | 0.88 | CHRM1 (0.41) | DRD2DRD4CHRM1CARM1PRMT6 | |
| SCHEMBL8665528 | 0.87 | CCR3 (0.40) | DRD2 | |
| SCHEMBL8665587 | 0.87 | AKT1 (0.36) | DRD2DRD4AKT1POLBDRD3 | |
| SCHEMBL8665214 | 0.86 | MCHR1 (0.37) | DRD2DRD4AKT1CHRM1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5827875-A | PYRROLIDINE DERIVATIVES; ANTIATHEROSCLEROSIS AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-10-27 | — | — | US | disclosed |