Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL28403214 | 0.88 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL7772669 | 0.88 | ALDH1A1 (0.63) | ALDH1A1RECQLHPGDKDM4ESMN1; SMN2 | |
| Phenoxyethanol SCHEMBL1563572 | 0.85 | ALDH1A1 (0.68) | ALDH1A1RECQLSMN1; SMN2GAATDP1 | |
| Salicylic Acid SCHEMBL3184806 | 0.80 | PKM (0.61) | ALDH1A1RECQLHPGDKDM4ESMN1; SMN2 | |
| Phthalic Acid SCHEMBL14976724 | 0.79 | ALDH1A1 (0.73) | ALDH1A1RECQLHPGDKDM4ESMN1; SMN2 | |
| Phthalic Acid SCHEMBL14976727 | 0.79 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL7767114 | 0.78 | LMNA (0.67) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 | |
| Methyl Salicylate SCHEMBL27697194 | 0.77 | TSHR (0.56) | ALDH1A1HPGDKDM4ESMN1; SMN2ALOX15 | |
| Methyl Salicylate SCHEMBL27645401 | 0.75 | TSHR (0.67) | ALDH1A1HPGDKDM4ECA12CA1 | |
| Salicylic Acid SCHEMBL28917222 | 0.74 | HPGD (0.62) | ALDH1A1HPGDKDM4ESMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817607-A1 | LIQUID CLEANSING FORMULATIONS | UNILEVER PLC (GB) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996029049-A1 | LIQUID CLEANSING FORMULATIONS | UNILEVER PLC (GB) | 1996-09-26 | — | — | WO | disclosed |