Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11097673 | 0.82 | GPR139 (0.63) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8596109 | 0.82 | GPR139 (0.56) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL12158277 | 0.81 | LMNA (0.61) | KMT2AALDH1A1TDP1LMNAHSD17B10 | |
| SCHEMBL28502817 | 0.79 | POLB (0.51) | KMT2AALDH1A1HDAC1HDAC6 | |
| SCHEMBL28502815 | 0.79 | POLB (0.51) | KMT2AALDH1A1HDAC1HDAC6 | |
| SCHEMBL11108039 | 0.78 | GPR139 (0.52) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8127118 | 0.77 | GPR139 (0.57) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL9398221 | 0.77 | GPR139 (0.53) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL7716214 | 0.77 | GPR139 (0.53) | GPR139KMT2AALDH1A1MAPTHTT | |
| SCHEMBL23154641 | 0.75 | GPR139 (0.45) | GPR139KMT2AALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710228-B1 | HYDRAZINO-TYPE RADIONUCLIDE CHELATORS HAVING AN N 3?S CONFIGURATION | RESOLUTION PHARM INC (CA) | 1998-01-21 | — | — | EP | disclosed |
| US-5659041-A | MEDICAL DIAGNOSIS, THERAPY | RESOLUTION PHARMACEUTICALS, INC. (CA) | 1997-08-19 | — | — | US | disclosed |
| EP-0710228-A1 | HYDRAZINO-TYPE RADIONUCLIDE CHELATORS HAVING AN N 3?S CONFIGURATION | RESOLUTION PHARMACEUTICALS INC. (CA) | 1996-05-08 | — | — | EP | disclosed |
| WO-1995003280-A1 | HYDRAZINO-TYPE RADIONUCLIDE CHELATORS HAVING AN N3S CONFIGURATION | RESOLUTION PHARMACEUTICALS INC. (CA) | 1995-02-02 | — | — | WO | disclosed |